Age-dependency of the serum oxidative level in the senescence-accelerated mouse prone 8

被引：6

作者：

Taniguchi, Sakiko ^{[1
]}

Hanafusa, Masakazu ^{[2
]}

Tsubone, Hirokazu ^{[2
]}

Takimoto, Haruka ^{[1
]}

Yamanaka, Daisuke ^{[3
]}

Kuwahara, Masayoshi ^{[1
]}

Ito, Koichi ^{[3
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pathophysiol & Anim Hlth, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Res Ctr Food Safety, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan

[3] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Food & Physiol Models, 3145 Ago, Kasama, Ibaraki 3190206, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 08期

关键词：

aging; BAP; d-ROM; oxidative stress; senescence-accelerated mouse; LONG-TERM POTENTIATION; CEREBRAL-CORTEX; STRESS; MODEL; SAM;

D O I：

10.1292/jvms.16-0204

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Systemic oxidative stress is considered to cause aging. In this study, to estimate the oxidative stress level in senescence-accelerated mouse prone 8 (SAMP8), we evaluated serum reactive oxygen species production and reduction capacity by measurement of Diacron-Reactive Oxygen Metabolites (d-ROM) and Biological Antioxidant Potential (BAP), respectively, with age. SAMP8 showed earlier increase of d-ROM value with age than SAM resistant 1 (SAMR1), the control strain. The BAP level was the highest in adult SAMP8, whereas SAMR1 presented the sustained BAP values between ages. These results indicate that oxidative stress in SAMP8 is higher than SAMR1. Our study is the first detailed report about d-ROM and BAP in SAMP8 and will provide useful fundamental data for future aging studies.

引用

页码：1369 / 1371

页数：3

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