Cephalexin loading and controlled release studies on mesoporous silica functionalized with amino groups

被引:15
作者
Montiel-Centeno, Kiara [1 ,2 ]
Barrera, Deicy [1 ]
Garcia-Villen, Fatima [2 ]
Sanchez-Espejo, Rita [2 ]
Borrego-Sanchez, Ana [2 ]
Rodriguez-Castellon, Enrique [3 ]
Sandri, Giuseppina [4 ]
Viseras, Cesar [2 ,5 ]
Sapag, Karim [1 ]
机构
[1] Univ Nacl San Luis, Lab Solidos Porosos, Inst Fis Aplicada, CONICET, Ejercito Andes 950, RA-5700 San Luis, Argentina
[2] Univ Granada, Deparment Pharm & Pharmaceut Technol, Granada 18071, Spain
[3] Univ Malaga, Fac Ciencias, Dept Quim Inorgan, Unidad Asociada Inst Catalisis CSIC, Malaga 29071, Spain
[4] Univ Pavia, Deparment Drug Sci, viale Tatamelli 12, I-22100 Pavia, Italy
[5] Univ Granada Armilla, Andalusian Inst Earth Sci, Consejo Super Invest Cient, Granada 18100, Spain
关键词
Cephalexin; Drug delivery system; Functionalization; KIT-6; Loading; Release; HYDROXYL-GROUPS; SBA-15; DRUG; ADSORPTION; SURFACE; NANOPARTICLES; PH; KIT-6; AMPICILLIN; IBUPROFEN;
D O I
10.1016/j.jddst.2022.103348
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
KIT-6 mesoporous silica has been synthesized using the sol-gel method and functionalized with 3-aminopropyl triethoxysilane by grafting route to obtain KIT-6/NH2. These samples were used as carriers in the loading and controlled release of cephalexin (CFX). The effect of temperature and gastric and intestinal pH on the stability of pure CFX and loaded in KIT-6 and KIT-6/NH2 were investigated. The properties of the synthesized materials and their CFX loading capacity were studied through FTIR, ads-des N2 at 77 K, TEM, SEM, XPS, and TGA. The controlled release tests were carried out in a simulated physiological medium at gastric (1.2) and intestinal pH (6.8). Furthermore, the biocompatibility of both materials was studied through cell viability tests in Caco-2 intestinal cells. The results revealed that KIT-6 and KIT-6/NH2 had similar CFX loading capacities. It was found that CFX degrades at pH 6.8, however, KIT-6 and KIT-6/NH2 were able to protect it from the aforemen-tioned degradation. Moreover, KIT-6 materials presented a good performance as CFX carriers since both mate-rials provided diffusion-controlled release profiles during 24 h, satisfying the Korsmeyer-Peppas kinetic model. Mesoporous silicas presented in this work are promising candidates to be used in CFX controlled release systems due to their chemical interactions, textural properties, and high cell viability.
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页数:12
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