Mitochondria-Lysosome Crosstalk: From Physiology to Neurodegeneration

被引：185

作者：

Deus, Claudia M. ^{[1
,2
]}

Yambire, King Faisal ^{[3
]}

Oliveira, Paulo J. ^{[1
,2
]}

Raimundo, Nuno ^{[3
]}

机构：

[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, UC Biotech, Biocant Pk, P-3060197 Cantanhede, Portugal

[2] Univ Coimbra, Inst Interdisciplinary Res, P-3030789 Coimbra, Portugal

[3] Univ Med Ctr Goettingen, Inst Cellular Biochem, D-37073 Gottingen, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 01期

基金：

欧洲研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; QUALITY-CONTROL; MOUSE MODEL; COMPLEX-I; REGULATE AUTOPHAGY; DISEASE; BIOGENESIS; AMPK; PHOSPHORYLATION; FISSION;

D O I：

10.1016/j.molmed.2019.10.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular function requires coordination between different organelles and metabolic cues. Mitochondria and lysosomes are essential for cellular metabolism as major contributors of chemical energy and building blocks. It is therefore pivotal for cellular function to coordinate the metabolic roles of mitochondria and lysosomes. However, these organelles do more than metabolism, given their function as fundamental signaling platforms in the cell that regulate many key pro cesses such as autophagy, proliferation, and cell death. Mechanisms of crosstalk between mitochondria and lysosomes are discussed, both under physiological conditions and in diseases that affect these organelles.

引用

页码：71 / 88

页数：18

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