Evaluation of the antioxidant effects of polysaccharides extracted from Lycium barbarum

被引:46
作者
Li, X. L. [1 ]
Zhou, A. G. [1 ]
机构
[1] Shi He Zi Univ, Hosp 1, Inst Med, Shi He 832008, Peoples R China
关键词
DPPH radical; In vitro; Lycium barbarum; polysaccharides; reducing power; scavenging activity;
D O I
10.1007/s00044-007-9002-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Lycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for many diseases. Polysaccharides are the most important functional constituent in Lycium barbarum fruits. In the present study, the antioxidant activity of polysaccharides extracted from Lycium barbarum fruits growing in Xin Jiang, a northwest province of China, was evaluated. Six established in vitro methods, including superoxide radical (O-2(-)) scavenging activity, reducing power, beta-carotene linoleate model, inhibition of mice erythrocyte hemolysis mediated by peroxyl free radicals, 1, 1-diphenyl-2 picrylhydrazyl (DPPH) radical-scavenging, and metal chelating activity were used in our evaluation. The polysaccharides showed considerable inhibitory activity in the beta-carotene-linoleate model system in a concentration-dependent manner. Further, they exhibited moderate concentration dependent inhibition of the DPPH radical. The multiple antioxidant activity of the polysaccharides was evidenced by significant reducing power, superoxide scavenging ability, inhibition of mice erythrocyte hemolysis mediated by peroxyl free radicals, and also ferrous ion chelating potency. The data obtained in the in vitro models clearly establish the antioxidant potency of the polysaccharides extracted from Lyceum barbarum fruits.
引用
收藏
页码:471 / 482
页数:12
相关论文
共 36 条
[1]   OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].
AMES, BN ;
SHIGENAGA, MK ;
HAGEN, TM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922
[2]   ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].
BLOIS, MS .
NATURE, 1958, 181 (4617) :1199-1200
[3]  
Dhuley J. N., 1993, Indian Journal of Experimental Biology, V31, P443
[4]   Role of serotonin2C receptors in the control of brain dopaminergic function [J].
Di Matteo, V ;
Cacchio, M ;
Di Giulio, C ;
Esposito, E .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 71 (04) :727-734
[5]   ACTION OF PHENOLIC DERIVATIVES (ACETAMINOPHEN, SALICYLATE, AND 5-AMINOSALICYLATE) AS INHIBITORS OF MEMBRANE LIPID-PEROXIDATION AND AS PEROXYL RADICAL SCAVENGERS [J].
DINIS, TCP ;
MADEIRA, VMC ;
ALMEIDA, LM .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1994, 315 (01) :161-169
[6]   Will the 'good fairies' please prove to us that vitamin E lessens human degenerative disease? [J].
Diplock, AT .
FREE RADICAL RESEARCH, 1997, 26 (06) :565-583
[7]   Fe(III) reductive and free radical-scavenging properties of summer savory (Satureja hortensis L.) extract and subfractions [J].
Dorman, HJD ;
Hiltunen, R .
FOOD CHEMISTRY, 2004, 88 (02) :193-199
[8]  
Duh Pin-Der, 1999, Lebensmittel-Wissenschaft and Technologie, V32, P269, DOI 10.1006/fstl.1999.0548
[10]  
[甘璐 Gan Lu], 2003, [营养学报, Acta Nutrimenta Sinica], V25, P200