Association of Dynamic Changes in Metabolic Syndrome Status with the Risk of Parkinson's Disease: A Nationwide Cohort Study

被引：11

作者：

Park, Sang Hyun ^{[1
]}

Nam, Ga Eun ^{[2
]}

Han, Kyungdo ^{[3
]}

Huh, Youn ^{[4
]}

Kim, Wonsock ^{[4
]}

Lee, Min-Kyung ^{[5
]}

Koh, Eun-Sil ^{[6
]}

Kim, Eun Sook ^{[7
]}

Kim, Mee Kyung ^{[8
]}

Kwon, Hyuk-Sang ^{[8
]}

Kim, Seon Mee ^{[2
]}

Cho, Kyung Hwan ^{[2
]}

Park, Yong Gyu ^{[9
]}

机构：

[1] Catholic Univ Korea, Grad Sch, Dept Biomed & Hlth Sci, Seoul, South Korea

[2] Korea Univ, Dept Family Med, Coll Med, Seoul, South Korea

[3] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea

[4] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Family Med, Gyeonggi Do, South Korea

[5] Hanyang Univ, Myongji Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Gyeonggi Do, South Korea

[6] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol,Yeouido St Marys Hosp, Seoul, South Korea

[7] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Incheon St Marys Hosp, Incheon, South Korea

[8] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Yeouido St Marys Hosp, Seoul, South Korea

[9] Catholic Univ Korea, Coll Med, Dept Med Lifesci, 222 Banpo Daero, Seoul 06591, South Korea

来源：

JOURNAL OF PARKINSONS DISEASE | 2021年 / 11卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Metabolic syndrome; Parkinson's disease; metabolic change; cohort; INSULIN-RESISTANCE; ALZHEIMERS; NEURODEGENERATION; HYPERTENSION; MORTALITY; OBESITY; MASS;

D O I：

10.3233/JPD-212589

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: The longitudinal association between dynamic changes in the metabolic syndrome (MS) status and Parkinson's disease (PD) has been poorly studied. Objective: We examined whether dynamic changes in MS status are associated with altered risk for PD. Methods: This study was a nationwide retrospective cohort study. We enrolled 5,522,813 individuals aged >= 40 years who had undergone health examinations under the National Health Insurance Service between 2009 and 2010 (two health examinations with a 2-year interval). Participants were followed up until the end of 2017. The participants were categorized into four groups according to MS status changes over 2 years: non-MS, improved MS, incident MS, and persistent MS groups. Multivariable Cox hazard regression was performed. Results: During the 7-year median follow-up, there were 20,524 cases of newly developed PD. Compared with non-MS group, improved, incident, and persistent MS groups for 2 years were significantly associated with higher risks of PD (model 3; hazard ratio: 1.12, 95% confidence interval: 1.06-1.19 [improved MS]; 1.15, 1.09-1.22 [incident MS]; and 1.25, 1.20-1.30 [persistent MS]). Individuals with incident and persistent abdominal obesity, low levels of high-density lipoprotein cholesterol, hypertriglyceridemia, and hyperglycemia had a significantly increased risks of PD compared with those without either condition over 2 years. Conclusion: Persistent and incident MS and its components may be risk factors for incident PD. Ever exposure to MS may also be associated with PD risk. Appropriate intervention for preventing and improving MS may be crucial in decreasing the PD incidence.

引用

页码：1751 / 1759

页数：9

共 35 条

[1] Cardioprotective effects of light-moderate consumption of alcohol: A review of putative mechanisms [J].