Cognitive Dysfunction after Cardiac Surgery

被引：7

作者：

Mehta, Yatin ^{[1
]}

Singh, Raveen ^{[1
]}

机构：

[1] Medanta, Dept Cardiac Anaesthesia, Sector 38, Medanta Inst Crit Care & Anaesthesiol, Gurgaon, India

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷

关键词：

Cardiac surgery; cardiopulmonary bypass; neurologic dysfunction; pathophysiology; CORONARY-ARTERY-BYPASS; AMYLOID-BETA-PEPTIDE; CLINICALLY RELEVANT CONCENTRATIONS; CARDIOPULMONARY BYPASS; GRAFT-SURGERY; NEUROCOGNITIVE FUNCTION; NONCARDIAC SURGERY; RANDOMIZED-TRIAL; ALZHEIMERS-DISEASE; ALPHA-STAT;

D O I：

10.3233/JAD-2010-100834

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both short and long term cognitive changes occur after cardiac surgery but the pathophysiology of these neurobehavioral changes remain incompletely understood. The cause of cognitive decline is most likely multifactorial and probably represents a complex interaction between cerebral microemboli, global cerebral hypoperfusion, inflammation, and genetic susceptibility. The problem of cognitive decline after cardiac surgery continues to increase as the surgical population becomes older and has more prevalent comorbid diseases. A better understanding of the etiology is essential to finding new preventive strategies as no definitive therapy exists for cognitive dysfunction.

引用

收藏

页码：S115 / S120

页数：6

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