Analysis of Multiple Bands on Serum Protein Immunofixation Electrophoresis: Challenge in Interpretation of Clonality in a Patient with Light Chain-Predominant Multiple Myeloma

被引：1
作者：
Nwogbo, Okechukwu V. [1 ]
Jin, Yulan [1 ]
Sliker, Taylor [1 ]
Wilhite, Dorian [1 ]
Singh, Gurmukh [1 ]
机构：
[1] Augusta Univ, Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA
来源：
LABORATORY MEDICINE | 2021年 / 52卷 / 05期
关键词：
Monoclonal gammopathy; light chain predominant multiple myeloma; immune-subtraction; polymeric immunoglobulin chains; multiple bands in SIFE; serum free light chains; QUANTIFICATION;
D O I：
10.1093/labmed/lmab001
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Sera from patients with multiple myeloma usually display a single monoclonal immunoglobulin band on serum protein immunofixation electrophoresis. Multiple bands may be seen if the myeloma is bi- or triclonal or if the monoclonal immunoglobulin has rheumatoid factor activity. We describe a patient with light chain-predominant IgA lambda myeloma; the patient's serum displayed 2 spatially distinct bands reacting for alpha heavy and lambda light chains. The methods used to establish monoclonality are addressed.
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收藏
页码：503 / 508
页数：6
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