Mussel-Inspired Electrospun Smart Magnetic Nanofibers for Hyperthermic Chemotherapy

被引：82

作者：

GhavamiNejad, Amin ^{[1
]}

Sasikala, Arathyram Ramachandra Kurup ^{[1
]}

Unnithan, Afeesh Rajan ^{[1
,2
]}

Thomas, Reju George ^{[3
]}

Jeong, Yong Yeon ^{[3
]}

Vatankhah-Varnoosfaderani, Mohammad ^{[4
]}

Stadler, Florian J. ^{[5
,6
,7
]}

Park, Chan Hee ^{[1
,2
]}

Kim, Cheol Sang ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Grad Sch, Dept Bionanosyst Engn, Jeonju 561756, South Korea

[2] Chonbuk Natl Univ, Mech Design Engn, Jeonju 561756, South Korea

[3] Chonnam Natl Univ, Sch Med, Hwasun Hosp, Dept Radiol, Gwangju 501746, South Korea

[4] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[5] Shenzhen Univ, Coll Mat Sci & Engn, Shenzhen 518060, Peoples R China

[6] Nanshan Dist Key Lab Biopolymers & Safety Evaluat, Shenzhen 518060, Peoples R China

[7] Shenzhen Key Lab Special Funct Mat, Shenzhen 518060, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2015年 / 25卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; CANCER; COATINGS; ADHESION; WATER; PH; ELASTOMER; APOPTOSIS; SURFACES;

D O I：

10.1002/adfm.201500389

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.

引用

页码：2867 / 2875

页数：9

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