Insights from Drosophila models of Alzheimer's disease

被引：19

作者：

Cowan, Catherine M. ^{[1
]}

Shepherd, David ^{[1
]}

Mudher, Amritpal ^{[1
]}

机构：

[1] Univ Southampton, Sch Biol Sci, Southampton SO16 7PX, Hants, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷

关键词：

Alzheimer's disease; amyloid; Drosophila; microtubule; tauopathy; wnt/wingless signalling; AMYLOID PRECURSOR PROTEIN; A-BETA; NEUROFIBRILLARY TANGLES; AXONAL-TRANSPORT; HYPERPHOSPHORYLATED-TAU; SYNAPTIC-TRANSMISSION; MOUSE MODELS; NEURODEGENERATION; TAUOPATHY; PHOSPHORYLATION;

D O I：

10.1042/BST0380988

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AD (Alzheimer's disease) is a neurodegenerative disorder characterized by the abnormal hyperphosphorylation and aggregation of the microtubule-associated protein tau and the misfolding and deposition of A beta peptide. The mechanisms by which tau and A beta become abnormal is not clearly understood, neither is it known what role either protein plays in the neurodegenerative process underlying AD. We have modelled aspects of AD in Drosophila melanogaster to shed light on these processes and to further our understanding of the relationship between tau and amyloid in this disease.

引用

页码：988 / 992

页数：5

共 47 条

[41] Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons [J].

Sinadinos, C. ;

Burbidge-King, T. ;

Soh, D. ;

Thompson, L. M. ;

Marsh, J. L. ;

Wyttenbach, A. ;

Mudher, A. K. .

NEUROBIOLOGY OF DISEASE, 2009, 34 (02) :389-395

[42] Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation [J].

Song, M. S. ;

Rauw, G. ;

Baker, G. B. ;

Kar, S. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 28 (10) :1989-2002

[43] Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau [J].

Takashima, A ;

Murayama, M ;

Murayama, O ;

Kohno, T ;

Honda, T ;

Yasutake, K ;

Nihonmatsu, N ;

Mercken, M ;

Yamaguchi, H ;

Sugihara, S ;

Wolozin, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9637-9641

[44]

Williams DW, 2000, J COMP NEUROL, V428, P630, DOI 10.1002/1096-9861(20001225)428:4<630::AID-CNE4>3.0.CO

[45]

2-X

[46] Tauopathy in Drosophila:: Neurodegeneration without neurofibrillary tangles [J].

Wittmann, CW ;

Wszolek, MF ;

Shulman, JM ;

Salvaterra, PM ;

Lewis, J ;

Hutton, M ;

Feany, MB .

SCIENCE, 2001, 293 (5530) :711-714

[47] Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment [J].

Yang, Tao ;

Knowles, Juliet K. ;

Lu, Qun ;

Zhang, Hong ;

Arancio, Ottavio ;

Moore, Laura A. ;

Chang, Timothy ;

Wang, Qian ;

Andreasson, Katrin ;

Rajadas, Jayakumar ;

Fuller, Gerald G. ;

Xie, Youmei ;

Massa, Stephen M. ;

Longo, Frank M. .

PLOS ONE, 2008, 3 (11)

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