Contribution of Chitinases to Listeria monocytogenes Pathogenesis

被引：64

作者：

Chaudhuri, Swarnava ^{[1
]}

Bruno, Joseph C. ^{[2
]}

Alonzo, Francis, III ^{[1
]}

Xayarath, Bobbi ^{[1
]}

Cianciotto, Nicholas P. ^{[3
]}

Freitag, Nancy E. ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60680 USA

[2] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[3] Northwestern Univ, Dept Microbiol & Immunol, Chicago, IL 60611 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2010年 / 76卷 / 21期

关键词：

VIBRIO-CHOLERAE; VIRULENCE; EPIDEMIOLOGY; SURVIVAL; GROWTH;

D O I：

10.1128/AEM.01338-10

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lacking chiA, chiB, or lmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus, L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

引用

页码：7302 / 7305

页数：4