2D protein arrays induce 3D in vivo-like assemblies of cells

被引：10

作者：

Moreno-Flores, S. ^{[1
]}

Kuepcue, S. ^{[2
]}

机构：

[1] Univ Nat Resources & Life Sci, A-1190 Vienna, Austria

[2] Univ Nat Resources & Life Sci, Dept Nanobiotechnol, Inst Synthet Bioarchitectures, A-1190 Vienna, Austria

来源：

SOFT MATTER | 2015年 / 11卷 / 07期

关键词：

MULTICELLULAR TUMOR SPHEROIDS; HEPATOCYTE SPHEROIDS; S-LAYERS; COCULTURE; POLARITY; CULTURE; MODEL;

D O I：

10.1039/c4sm02278e

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report on the ability of two-dimensional protein crystals to induce the formation of homo-and heterotypic multicellular spheroids (MCSs) which resemble the morphology and hierarchical organization of living tissues and tumours. We have systematically studied the influence of the initial cell density and incubation time on the kinetics of spheroid growth and spheroid lifespan. Hereby a novel methodology has been established to produce MCSs on protein-based molecular layers.

引用

页码：1259 / 1264

页数：6

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