Kidney Injury Molecule 1 (KIM-1): a Multifunctional Glycoprotein and Biological Marker (Review)

被引：69

作者：

Karmakova, T. A. ^{[1
]}

Sergeeva, N. S. ^{[1
,2
]}

Kanukoev, K. Yu ^{[3
]}

Alekseev, B. Ya ^{[4
]}

Kaprin, A. D. ^{[5
,6
]}

机构：

[1] Minist Hlth Russian Federat, P Hertsen Moscow Oncol Res Inst, Natl Med Res Radiol Ctr, Dept Predicting Effectiveness Conservat Therapy, 3 2nd Botkinsky Proezd, Moscow 125284, Russia

[2] Pirogov Russian Natl Res Med Univ, Dept Biol, 1 Ostrovitianova St, Moscow 117997, Russia

[3] Minist Hlth Russian Federat, P Hertsen Moscow Oncol Res Inst, Natl Med Res Radiol Ctr, Dept Urol Chemotherapy, 3 2nd Botkinsky Proezd, Moscow 125284, Russia

[4] Minist Hlth Russian Federat, Natl Med Res Radiol Ctr, Sci, 4 Koroleva St, Obninsk 249036, Russia

[5] Russian Acad Sci, Natl Med Res Radiol Ctr, Minist Hlth Russian Federat, 4 Koroleva St, Obninsk 249036, Russia

[6] Minist Hlth Russian Federat, Natl Med Res Radiol Ctr, 4 Koroleva St, Obninsk 249036, Russia

来源：

SOVREMENNYE TEHNOLOGII V MEDICINE | 2021年 / 13卷 / 03期

关键词：

KIM-1; HAVcr-1; TIM-1; regulation of immune reactions; acute kidney injury; chronic renal failure; heart failure; renal cell carcinoma; RENAL-CELL CARCINOMA; GELATINASE-ASSOCIATED LIPOCALIN; REGULATORY B-CELLS; TIM GENE FAMILY; MUCIN DOMAIN; URINARY BIOMARKERS; PROGNOSTIC VALUE; APOPTOTIC CELLS; IGA NEPHROPATHY; TUBULAR INJURY;

D O I：

10.17691/stm2021.13.3.08

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

KIM-1 (kidney injury molecule 1) is a transmembrane glycoprotein also known as HAVcr-1 and TIM-1 belongs to the T-cell immunoglobulin and mucin domain family (TIM) of proteins. TIM glycoproteins are presented on the immune cells and participate in the regulation of immune reactions. KIM-1 differs from other members of its family in that it is expressed not only by immunocompetent cells but epithelial cells as well. Cellular and humoral effects mediated by KIM-1 are involved in a variety of physiological and pathophysiological processes. Current understanding of the mechanisms determining the participation of KIM-1 in viral invasion, the immune response regulation, adaptive reactions of the kidney epithelium to acute ischemic or toxic injury, in progression of chronic renal diseases, and kidney cancer development have been presented in this review. Data of clinical researches demonstrating the association of KIM-1 with viral diseases and immune disorders have also been analyzed. Potential application of KIM-1 as urinary or serological marker in renal and cardiovascular diseases has been considered.

引用

页码：64 / 78

页数：15

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