Genetics of inflammatory bowel disease - The beginning of the end or the end of the beginning?

被引：20
作者：
Annese, V [1 ]
Latiano, A
Andriulli, A
机构：
[1] Casa Sollievo Sofferenza Hosp, IRCCS, Dept Internal Med, Gastroenterol Unit, I-71013 San Giovanni Rotondo, FG, Italy
[2] Casa Sollievo Sofferenza Hosp, IRCCS, Mol Biol Lab, I-71013 San Giovanni Rotondo, FG, Italy
来源：
DIGESTIVE AND LIVER DISEASE | 2003年 / 35卷 / 06期
关键词：
Crohn's disease; gene; inflammatory bowel disease; NOD2/CARD(15); ulcerative colitis;
D O I：
10.1016/S1590-8658(03)00213-5
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Recent identification of the first susceptibility gene for Crohn's disease has led to increasing enthusiasm for the investigation and dissection of inflammatory bowel disease. In the future, identification of additional genes and careful correlation of the genetic background with clinical features of the disease will help to elucidate the causes and cure of inflammatory bowel disease. However, caution is still needed in the short term since our present knowledge has limited influence on clinical management. This review focuses on the genetic background of inflammatory bowel disease, the process of discovering the mutations of the NOD2/CARD(15) gene in Crohn's disease patients, and the functional clues of the genetic variants of this gene in relation to clinical features. (C) 2003 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：442 / 449
页数：8
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