Management of Stage IIB Cervical Cancer: an Overview of the Current Evidence

被引：15

作者：

Matsuzaki, Shinya ^{[1
]}

Klar, Maximilian ^{[2
]}

Mikami, Mikio ^{[3
]}

Shimada, Muneaki ^{[4
]}

Grubbs, Brendan H. ^{[5
]}

Fujiwara, Keiichi ^{[6
]}

Roman, Lynda D. ^{[1
,7
]}

Matsuo, Koji ^{[1
,7
]}

机构：

[1] Univ Southern Calif, Div Gynecol Oncol, Dept Obstet & Gynecol, 2020 Zonal Ave IRD520, Los Angeles, CA 90033 USA

[2] Univ Freiburg, Dept Obstet & Gynecol, Freiburg, Germany

[3] Tokai Univ, Sch Med, Dept Obstet & Gynecol, Isehara, Kanagawa, Japan

[4] Tohoku Univ, Dept Obstet & Gynecol, Sch Med, Sendai, Miyagi, Japan

[5] Univ Southern Calif, Div Maternal Fetal Med, Dept Obstet & Gynecol, Los Angeles, CA 90007 USA

[6] Saitama Med Univ, Int Med Ctr, Dept Gynecol Oncol, Saitama, Japan

[7] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA

来源：

CURRENT ONCOLOGY REPORTS | 2020年 / 22卷 / 03期

关键词：

Cervical cancer; Stage II; Concurrent chemoradiotherapy; Neoadjuvant chemotherapy; Radical hysterectomy; Survival; SQUAMOUS-CELL-CARCINOMA; FLUOROURACIL PLUS CISPLATIN; RANDOMIZED CONTROLLED-TRIAL; GYNECOLOGIC-ONCOLOGY-GROUP; NEOADJUVANT CHEMOTHERAPY; RADICAL HYSTERECTOMY; PHASE-III; CONCURRENT CHEMORADIATION; CONCOMITANT CHEMOTHERAPY; ADJUVANT RADIOTHERAPY;

D O I：

10.1007/s11912-020-0888-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of Review To review and discuss the present evidence of surgery- and radiation-based treatment strategies for stage IIB cervical cancer. Recent Findings Recently, two randomized controlled trials compared the efficacy of neoadjuvant chemotherapy followed by radical hysterectomy (NACT + RH) with that of concurrent chemoradiotherapy (CCRT) for stage IB3-IIB cervical cancer. When these studies were combined (N = 1259), NACT + RH was associated with a shorter disease-free survival [hazard ratio (HR) 1.36, 95% confidence interval (CI) 1.13-1.64], but with a similar overall survival (HR 1.11, 95% CI 0.90-1.36) when compared with the findings for CCRT. Stage-specific analysis for stage IIB cervical cancer demonstrated that disease-free survival was significantly worse with NACT + RH than with CCRT (HR 1.90, 95% CI 1.25-2.89); however, no significant difference was observed for stage IB3-IIA cervical cancer. Based on the results of recent level I evidence, the standard treatment for stage IIB cervical cancer remains CCRT.

引用

页数：15

共 96 条

[71] Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix [J].

Peters, WA ;

Liu, PY ;

Barrett, RJ ;

Stock, RJ ;

Monk, BJ ;

Berek, JS ;

Souhami, L ;

Grigsby, P ;

Gordon, W ;

Alberts, DS .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (08) :1606-1613

[72] Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in Gynecologic Oncology Group trials of cisplatin-based chemoradiation [J].

Rose, Peter G. ;

Java, James J. ;

Whitney, Charles W. ;

Stehman, Frederick B. ;

Lanciano, Rachelle ;

Thomas, Gillian M. .

GYNECOLOGIC ONCOLOGY, 2014, 135 (02) :208-212

[73] Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer [J].

Rose, PG ;

Bundy, BN ;

Watkins, EB ;

Thigpen, JT ;

Deppe, G ;

Maiman, MA ;

Clarke-Pearson, DL ;

Insalaco, S .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (15) :1144-1153

[74] Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer [J].

Rydzewska, Larysa ;

Tierney, Jayne ;

Vale, Claire L. ;

Symonds, Paul R. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (12)

[75] Annual Report of the Committee on Gynecologic Oncology, Japan Society of Obstetrics and Gynecology: Patient Annual Report for 2013 and Treatment Annual Report for 2008 [J].

Saito, Toshiaki ;

Katabuchi, Hidetaka .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2016, 42 (09) :1069-1079

[76] The Added Role of MR Imaging in Treatment Stratification of Patients with Gynecologic Malignancies: What the Radiologist Needs to Know [J].

Sala, Evis ;

Rockall, Andrea G. ;

Freeman, Susan J. ;

Mitchell, Donald G. ;

Reinhold, Caroline .

RADIOLOGY, 2013, 266 (03) :717-740

[77] Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: The final results [J].

Sardi, JE ;

Giaroli, A ;

Sananes, C ;

Ferreira, M ;

Soderini, A ;

Bermudez, A ;

Snaidas, L ;

Vighi, S ;

Rueda, NG ;

diPaola, G .

GYNECOLOGIC ONCOLOGY, 1997, 67 (01) :61-69

[78] Efficacy and tolerability of paclitaxel, ifosfamide, and cisplatin as a neoadjuvant chemotherapy in locally advanced cervical carcinoma [J].

Scandurra, Giuseppa ;

Scibilia, Giuseppe ;

Banna, Giuseppe Luigi ;

D'Agate, Gabriella ;

Lipari, Helga ;

Gieri, Stefania ;

Scollo, Paolo .

JOURNAL OF GYNECOLOGIC ONCOLOGY, 2015, 26 (02) :118-124

[79] Concurrent chemotherapy and radiation therapy in primary cancer of the cervix. [J].

Schilder J.M. ;

Stehman F.B. .

Current Oncology Reports, 1999, 1 (1) :41-46

[80] Neoadjuvant chemotherapy with docetaxel and carboplatin followed by radical hysterectomy for stage IB2, IIA2, and IIB patients with non-squamous cell carcinoma of the uterine cervix [J].

Shimada, Muneaki ;

Nagao, Shoji ;

Fujiwara, Keiichi ;

Takeshima, Nobuhiro ;

Takizawa, Ken ;

Shoji, Tadahiro ;

Sugiyama, Toru ;

Yamaguchi, Satoshi ;

Nishimura, Ryuichiro ;

Kigawa, Junzo .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2016, 21 (06) :1128-1135

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