Animal models of gastrointestinal and liver diseases. Animal models of cystic fibrosis: gastrointestinal, pancreatic, and hepatobiliary disease and pathophysiology

被引：37

作者：

Olivier, Alicia K.

Gibson-Corley, Katherine N.

Meyerholz, David K. ^{[1
]}

机构：

[1] Univ Iowa, Dept Pathol, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2015年 / 308卷 / 06期

关键词：

cystic fibrosis; gastrointestinal tract; liver; pancreas; cystic fibrosis transmembrane conductance regulator; TRANSMEMBRANE CONDUCTANCE REGULATOR; INTESTINE BACTERIAL OVERGROWTH; SMOOTH-MUSCLE DYSFUNCTION; EXOCRINE PANCREAS; INFLAMMATORY RESPONSE; BILIARY EPITHELIUM; MECONIUM ILEUS; MOUSE MODELS; CFTR; GENE;

D O I：

10.1152/ajpgi.00146.2014

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Multiple organ systems, including the gastrointestinal tract, pancreas, and hepatobiliary systems, are affected by cystic fibrosis (CF). Many of these changes begin early in life and are difficult to study in young CF patients. Recent development of novel CF animal models has expanded opportunities in the field to better understand CF pathogenesis and evaluate traditional and innovative therapeutics. In this review, we discuss manifestations of CF disease in gastrointestinal, pancreatic, and hepatobiliary systems of humans and animal models. We also compare the similarities and limitations of animal models and discuss future directions for modeling CF.

引用

页码：G459 / G471

页数：13

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