Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

被引：6

作者：

Autore, Francesco ^{[1
]}

Piccirillo, Nicola ^{[1
,2
]}

Nozza, Andrea ^{[3
]}

Innocenti, Idanna ^{[1
]}

Putzulu, Rossana ^{[1
]}

Chiusolo, Patrizia ^{[1
,2
]}

Sora, Federica ^{[1
,2
]}

Zini, Gina ^{[1
,2
]}

Bacigalupo, Andrea ^{[1
,2
]}

Castagna, Luca ^{[3
]}

Sica, Simona ^{[1
,2
]}

Bramanti, Stefania ^{[3
]}

Laurenti, Luca ^{[1
,2
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[2] Univ Cattolica Sacro Cuore, Ist Ematol, Rome, Italy

[3] Humanitas Canc Ctr, Milan, Italy

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2019年 / 25卷 / 12期

关键词：

POEMS syndrome; Mobilizing regimen; Peripheral blood hemopoietic stem cell; Cyclophosphamide; G-CSF; TRANSPLANTATION;

D O I：

10.1016/j.bbmt.2019.08.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34(+) cell dose. (C) 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.

引用

页码：2514 / 2516

页数：3

共 12 条

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