Peripheral Blood Hemopoietic Stem Cell Mobilization Regimens in POEMS Syndrome: A Retrospective Study at 2 Hematologic Italian Centers

被引:6
作者
Autore, Francesco [1 ]
Piccirillo, Nicola [1 ,2 ]
Nozza, Andrea [3 ]
Innocenti, Idanna [1 ]
Putzulu, Rossana [1 ]
Chiusolo, Patrizia [1 ,2 ]
Sora, Federica [1 ,2 ]
Zini, Gina [1 ,2 ]
Bacigalupo, Andrea [1 ,2 ]
Castagna, Luca [3 ]
Sica, Simona [1 ,2 ]
Bramanti, Stefania [3 ]
Laurenti, Luca [1 ,2 ]
机构
[1] Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Ist Ematol, Rome, Italy
[3] Humanitas Canc Ctr, Milan, Italy
关键词
POEMS syndrome; Mobilizing regimen; Peripheral blood hemopoietic stem cell; Cyclophosphamide; G-CSF; TRANSPLANTATION;
D O I
10.1016/j.bbmt.2019.08.011
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Autologous peripheral blood stem cell transplantation should be considered first-line therapy in young patients with POEMS. The best protocol to collect peripheral blood stem cells remains to be defined, because of the disease rarity and the heterogeneity of published case series. We collected clinical and laboratory data from 25 patients undergoing mobilization, of whom 11 were mobilized using cyclophosphamide (CY) followed by granulocyte colony-stimulating factor (G-CSF) and 14 patients using G-CSF. The incidence of poor mobilization was low and not statistically different between the 2 groups. Both schemes (CY plus G-CSF versus G-CSF alone) were able to harvest a sufficient CD34(+) cell dose. (C) 2019 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
引用
收藏
页码:2514 / 2516
页数:3
相关论文
共 12 条
[1]   Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome [J].
Autore, Francesco ;
Innocenti, Idanna ;
Luigetti, Marco ;
Piccirillo, Nicola ;
Sora, Federica ;
Chiusolo, Patrizia ;
Sica, Simona ;
Bacigalupo, Andrea ;
Laurenti, Luca .
HEMATOLOGICAL ONCOLOGY, 2018, 36 (02) :392-398
[2]   PLASMA-CELL DYSCRASIA WITH POLYNEUROPATHY, ORGANOMEGALY, ENDOCRINOPATHY, M PROTEIN, AND SKIN CHANGES - THE POEMS SYNDROME - REPORT ON 2 CASES AND A REVIEW OF THE LITERATURE [J].
BARDWICK, PA ;
ZVAIFLER, NJ ;
GILL, GN ;
NEWMAN, D ;
GREENWAY, GD ;
RESNICK, DL .
MEDICINE, 1980, 59 (04) :311-322
[3]   Peripheral blood stem cell transplantation in 16 patients with POEMS syndrome: and a review of the literature [J].
Dispenzieri, A ;
Moreno-Aspitia, A ;
Suarez, GA ;
Lacy, MQ ;
Colon-Otero, G ;
Tefferi, A ;
Litzow, MR ;
Roy, V ;
Hogan, WJ ;
Kyle, RA ;
Gertz, MA .
BLOOD, 2004, 104 (10) :3400-3407
[4]   POEMS syndrome: definitions and long-term outcome [J].
Dispenzieri, A ;
Kyle, RA ;
Lacy, MQ ;
Rajkumar, SV ;
Therneau, TM ;
Larson, DR ;
Greipp, PR ;
Witzig, TE ;
Basu, R ;
Suarez, GA ;
Fonseca, R ;
Lust, JA ;
Gertz, MA .
BLOOD, 2003, 101 (07) :2496-2506
[5]   POEMS syndrome: 2011 update on diagnosis, risk-stratification, and management [J].
Dispenzieri, Angela .
AMERICAN JOURNAL OF HEMATOLOGY, 2011, 86 (07) :592-601
[6]   Successful treatment of POEMS syndrome with autologous hematopoietic progenitor cell transplantation [J].
Hogan, WJ ;
Lacy, MQ ;
Wiseman, GA ;
Fealey, RD ;
Dispenzieri, A ;
Gertz, MA .
BONE MARROW TRANSPLANTATION, 2001, 28 (03) :305-309
[7]   High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome [J].
Jaccard, A ;
Royer, B ;
Bordessoule, D ;
Brouet, JC ;
Fermand, JP .
BLOOD, 2002, 99 (08) :3057-3059
[8]   Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation [J].
Jimenez-Zepeda, Victor H. ;
Trudel, Suzanne ;
Reece, Donna E. ;
Chen, Christine ;
Rabea, Ahmed M. ;
Kukreti, Vishal .
AMERICAN JOURNAL OF HEMATOLOGY, 2011, 86 (10) :873-875
[9]  
Laurenti L, 2000, HAEMATOLOGICA, V85, P782
[10]  
Laurenti L, 1998, HAEMATOLOGICA, V83, P138