Chemical synthesis of the pentasaccharide related to the anti-inflammatory oleanane type saponins isolated from medicinal plant Aster tataricus L. f.

被引：2

作者：

Bera, Madhumita ^{[1
]}

Mukhopadhyay, Balaram ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Sweet Lab, Naida 741246, India

来源：

CARBOHYDRATE RESEARCH | 2022年 / 516卷

关键词：

Saponin; Anti-inflammatory; Glycosylation; Oligosaccharide; Apiose; GLYCOSIDES; CHEMISTRY; BIOSYNTHESIS;

D O I：

10.1016/j.carres.2022.108563

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Total synthesis of the pentasaccharide related to the saponin isolated from the medicinal plant Aster tataricus L. f. is reported in the form of its allyl glycoside. The synthesis is accomplished by following a [3 + 2] block synthesis strategy where the trisaccharide acceptor and the disaccharide donor are rationally designed and obtained from semi-protected monosaccharides through stereoselective glycosylations either by activation of the thioglycoside or glycosyl trichloroacetimidate. The apiose moiety has been synthesized by literature procedure with little modification. The target pentasaccharide in the form of its allyl glycoside will be beneficial for further biological evaluation of the said structure and possible glycoconjugate formation as per need.

引用

页数：6

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