Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance

被引：37

作者：

Bottery, Michael J. ^{[1
]}

Wood, A. Jamie ^{[1
,2
]}

Brockhurst, Michael A. ^{[1
]}

机构：

[1] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England

[2] Univ York, Dept Math, York YO10 5DD, N Yorkshire, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 04期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

MECHANISMS;

D O I：

10.1128/AAC.02441-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid in Escherichia coli depend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

引用

页码：2524 / 2527

页数：4

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