Anti-TNF-α therapies in chronic obstructive pulmonary diseases

被引：21

作者：

Antoniu, Sabina A. ^{[1
]}

Mihaltan, Florin ^{[2
]}

Ulmeanu, Ruxandra ^{[3
]}

机构：

[1] Gr T Popa Univ Med & Pharm Iasi, Div Pulm Dis, Pulm Dis Univ Hosp, Iasi 700115, Romania

[2] Carol Davila Univ Med & Pharm Bucharest, Div Pulm Dis, Inst Pneumol M Nasta, Bucharest 050159, Romania

[3] Inst Pneumol M Nasta, Bronchol Dept, Bucharest 050159, Romania

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2008年 / 17卷 / 08期

关键词：

asthma; COPD; etanercept; infliximab; TNF-alpha;

D O I：

10.1517/13543784.17.8.1203

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Chronic obstructive pulmonary disease (COPD) and asthma are chronic diseases in which inflammation of the airways leads to progressive transient airway obstruction and TNF-alpha plays an important pro-inflammatory role. Objective: To assess the plausibility of anti-TNF-alpha therapies playing an anti-inflammatory role in asthma and COPD. Methods: Scientific rationale of TNF-alpha targeting in asthma and COPD was assessed individually and the available data on the use of anti-TINIF-alpha in each disease were reviewed. Results and conclusion: Anti-TNF-alpha therapies demonstrate different efficacies in asthma and COPD and further supportive preclinical and clinical data are needed, especially about subsets of certain diseases which could benefit the most from these therapies.

引用

页码：1203 / 1211

页数：9

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