Regulation of Neural Stem Cells in the Human SVZ by Trophic and Morphogenic Factors

被引：0

作者：

Alvarez-Palazuelos, Lucia E. ^{[2
]}

Robles-Cervantes, Martha S. ^{[3
]}

Castillo-Velazquez, Gabriel ^{[4
]}

Rivas-Souza, Mario ^{[3
]}

Guzman-Muniz, Jorge

Moy-Lopez, Norma

Gonzalez-Castaneda, Rocio E. ^{[2
]}

Luquin, Sonia ^{[2
]}

Gonzalez-Perez, Oscar ^{[1
,2
]}

机构：

[1] Univ Colima, Fac Psicol, Lab Neurosci, Colima 28040, COL, Mexico

[2] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Neurosci, Guadalajara, Jalisco, Mexico

[3] Inst Jalisciense Ciencias Forenses, Guadalajara, Jalisco, Mexico

[4] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Dept Neurosurg, Mexico City, DF, Mexico

来源：

CURRENT SIGNAL TRANSDUCTION THERAPY | 2011年 / 6卷 / 03期

关键词：

Subventricular zone; neural stem cell; human; neurodegenerative; astrocyte; ADULT SUBVENTRICULAR ZONE; ENDOTHELIAL GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; IN-VIVO; HUMAN BRAIN; OLFACTORY-BULB; PROGENITOR CELLS; SONIC HEDGEHOG; NEUROLOGICAL DISEASES; CELLULAR COMPOSITION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The subventricular zone (SVZ), lining the lateral ventricular system, is the largest germinal region in mammals. In there, neural stem cells express markers related to astroglial lineage that give rise to new neurons and oligodendrocytes in vivo. In the adult human brain, in vitro evidence has also shown that astrocytic cells isolated from the SVZ can generate new neurons and oligodendrocytes. These proliferative cells are strongly controlled by a number of signals and molecules that modulate, activate or repress the cell division, renewal, proliferation and fate of neural stem cells. In this review, we summarize the cellular composition of the adult human SVZ (hSVZ) and discuss the increasing evidence showing that some trophic modulators strongly control the function of neural stem cells in the SVZ.

引用

页码：320 / 326

页数：7

共 116 条

[1] Adult neurogenesis: From precursors to network and physiology
Abrous, DN
Koehl, M
Le Moal, M
[J]. PHYSIOLOGICAL REVIEWS, 2005, 85 (02) : 523 - 569
[2] β-Catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone
Adachi, Kazuhide
Mirzadeh, Zaman
Sakaguchi, Masanori
Yamashita, Toru
Nikolcheva, Tania
Gotoh, Yukiko
Peltz, Gary
Gong, Leyi
Kawase, Takeshi
Alvarez-Buylla, Arturo
Okano, Hideyuki
Sawamoto, Kazunobu
[J]. STEM CELLS, 2007, 25 (11) : 2827 - 2836
[3] Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
Aguirre, Adan
Rubio, Maria E.
Gallo, Vittorio
[J]. NATURE, 2010, 467 (7313) : 323 - U101
[4] The Culture of Neural Stem Cells
Ahmed, Sohail
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 106 (01) : 1 - 6
[5] In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
Ahn, S
Joyner, AL
[J]. NATURE, 2005, 437 (7060) : 894 - 897
[6] AUTORADIOGRAPHIC AND HISTOLOGICAL STUDIES OF POSTNATAL NEUROGENESIS .I. A LONGITUDINAL INVESTIGATION OF KINETICS MIGRATION AND TRANSFORMATION OF CELLS INCORPORATING TRITIATED THYMIDINE IN NEONATE RATS WITH SPECIAL REFERENCE TO POSTNATAL NEUROGENESIS IN SOME BRAIN REGIONS
ALTMAN, J
DAS, GD
[J]. JOURNAL OF COMPARATIVE NEUROLOGY, 1966, 126 (03) : 337 - &
[7] Alvarez-Buylla A, 2000, Prog Brain Res, V127, P1
[8] A unified hypothesis on the lineage of neural stem cells
Alvarez-Buylla, A
García-Verdugo, JM
Tramontin, AD
[J]. NATURE REVIEWS NEUROSCIENCE, 2001, 2 (04) : 287 - 293
[9] Characterization of Neural Stem/Progenitor Cells Expressing VEGF and its Receptors in the Subventricular Zone of Newborn Piglet Brain
Ara, Jahan
Fekete, Saskia
Zhu, Anli
Frank, Melissa
[J]. NEUROCHEMICAL RESEARCH, 2010, 35 (09) : 1455 - 1470
[10] Multipotent cell lineages in early mouse development depend on SOX2 function
Avilion, AA
Nicolis, SK
Pevny, LH
Perez, L
Vivian, N
Lovell-Badge, R
[J]. GENES & DEVELOPMENT, 2003, 17 (01) : 126 - 140

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