Ugi-Smiles Couplings of 4-Substituted Pyridine Derivatives: A Fast Access to Chloroquine Analogues

被引：19
作者：
El Kaim, Laurent [1 ]
Grimaud, Laurence [1 ]
Pravin, Patil [1 ]
机构：
[1] Ecole Natl Super Tech Avancees, DCSO UMR 7652, CNRS ENSTA Ecole Polytech, Lab Chim & Proc, F-75739 Paris 15, France
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 02期
关键词：
ANTIMALARIAL-DRUG DISCOVERY; MULTICOMPONENT REACTIONS; ANTIPLASMODIAL ACTIVITY; CATALYZED AMINATION; HETEROARYL; SCAFFOLDS; CHEMISTRY; ALKYL;
D O I：
10.1021/ol202974w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Hydroxy and mercapto pyridines were successfully tested in Ugi-Smiles couplings. Such multicomponent reactions applied to quinoline derivatives afford a very convenient and short synthesis of antimalarial analogues.
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收藏
页码：476 / 478
页数：3
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