Alkylation of 2-phenyl-4-quinolones: Synthetic and structural studies

被引：44

作者：

Hadjeri, M ^{[1
]}

Mariotte, AM ^{[1
]}

Boumendjel, A ^{[1
]}

机构：

[1] Grenoble Pharm Sch, UNRS, UMR 5063, Lab Pharmacognosy, F-3870 La Tornche, France

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 10期

关键词：

2-phenyl-4-quinolone; N-alkylation; regioselectivity;

D O I：

10.1248/cpb.49.1352

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and the NMR structural studies are reported.

引用

页码：1352 / 1355

页数：4

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