MetabNet: an R package for metabolic association analysis of high-resolution metabolomics data

被引：37

作者：

Uppal, Karan ^{[1
]}

Soltow, Quinlyn A. ^{[1
]}

Promislow, Daniel E. L. ^{[2
]}

Wachtman, Lynn M. ^{[3
]}

Quyyumi, Arshed Ali ^{[4
]}

Jones, Dean P. ^{[1
]}

机构：

[1] Emory Univ, Dept Med, Div Pulm Med, Atlanta, GA 30322 USA

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[3] Harvard Univ, New England Reg Primate Res Ctr, Southborough, MA USA

[4] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2015年 / 3卷

关键词：

metabolomics; metabolite identification; metabolic networks; metabolic pathways; targeted MWAS; choline;

D O I：

10.3389/fbioe.2015.00087

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Liquid-chromatography high-resolution mass spectrometry provides capability to measure >40,000 ions derived from metabolites in biologic samples. This presents challenges to confirm identities of known chemicals and delineate potential metabolic pathway associations of unidentified chemicals. We provide an R package for metabolic network analysis, MetabNet, to perform targeted metabolome-wide association study of specific metabolites to facilitate detection of their related metabolic pathways and network structures.

引用

页数：6