What Really Rigs Up RIG-I?

被引:20
作者
Barik, Sailen [1 ,2 ]
机构
[1] Cleveland State Univ, Dept Biol Geol & Environm Sci, 2121 Euclid Ave, Cleveland, OH 44115 USA
[2] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis, 2121 Euclid Ave, Cleveland, OH 44115 USA
关键词
Retinoic acid-inducible gene 1; Pathogen-associated molecular patterns; Leader-read-through transcript; 5 '-Triphosphate; Viral RNAs; RESPIRATORY SYNCYTIAL VIRUS; VESICULAR STOMATITIS-VIRUS; DOUBLE-STRANDED-RNA; E3 UBIQUITIN LIGASE; HEPATITIS-C VIRUS; STRUCTURAL BASIS; VIRAL-RNA; INTERFERON INDUCTION; INNATE IMMUNITY; MEASLES-VIRUS;
D O I
10.1159/000447947
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
RIG-I (retinoic acid-inducible gene 1) is an archetypal member of the cytoplasmic DEAD-box dsRNA helicase family (RIG-I-like receptors or RLRs), the members of which play essential roles in the innate immune response of the metazoan cell. RIG-I functions as a pattern recognition receptor that detects nonself RNA as a pathogen-associated molecular pattern (PAMP). However, the exact molecular nature of the viral RNAs that act as a RIG-I ligand has remained a mystery and a matter of debate. In this article, we offer a critical review of the actual viral RNAs that act as PAMPs to activate RIG-I, as seen from the perspective of a virologist, including a recent report that the viral Leader-read-through transcript is a novel and effective RIG-I ligand. (C) 2016 S. Karger AG, Basel
引用
收藏
页码:429 / 436
页数:8
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