What Really Rigs Up RIG-I?

被引：20

作者：

Barik, Sailen ^{[1
,2
]}

机构：

[1] Cleveland State Univ, Dept Biol Geol & Environm Sci, 2121 Euclid Ave, Cleveland, OH 44115 USA

[2] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis, 2121 Euclid Ave, Cleveland, OH 44115 USA

来源：

JOURNAL OF INNATE IMMUNITY | 2016年 / 8卷 / 05期

关键词：

Retinoic acid-inducible gene 1; Pathogen-associated molecular patterns; Leader-read-through transcript; 5 '-Triphosphate; Viral RNAs; RESPIRATORY SYNCYTIAL VIRUS; VESICULAR STOMATITIS-VIRUS; DOUBLE-STRANDED-RNA; E3 UBIQUITIN LIGASE; HEPATITIS-C VIRUS; STRUCTURAL BASIS; VIRAL-RNA; INTERFERON INDUCTION; INNATE IMMUNITY; MEASLES-VIRUS;

D O I：

10.1159/000447947

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

RIG-I (retinoic acid-inducible gene 1) is an archetypal member of the cytoplasmic DEAD-box dsRNA helicase family (RIG-I-like receptors or RLRs), the members of which play essential roles in the innate immune response of the metazoan cell. RIG-I functions as a pattern recognition receptor that detects nonself RNA as a pathogen-associated molecular pattern (PAMP). However, the exact molecular nature of the viral RNAs that act as a RIG-I ligand has remained a mystery and a matter of debate. In this article, we offer a critical review of the actual viral RNAs that act as PAMPs to activate RIG-I, as seen from the perspective of a virologist, including a recent report that the viral Leader-read-through transcript is a novel and effective RIG-I ligand. (C) 2016 S. Karger AG, Basel

引用

页码：429 / 436

页数：8

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