New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics

被引：112

作者：

Geddes-McAlister, Jennifer ^{[1
,2
]}

Shapiro, Rebecca S. ^{[1
]}

机构：

[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON N1G 2W1, Canada

[2] Max Planck Inst Biochem, Dept Prote & Signal Transduct, Munich, Germany

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2019年 / 1435卷 / 01期

关键词：

fungal pathogens; emerging pathogens; antifungal drug resistance; IN-VITRO ACTIVITY; DESORPTION IONIZATION-TIME; BROAD-SPECTRUM ANTIFUNGAL; FLIGHT MASS-SPECTROMETRY; ANTIMICROBIAL SURVEILLANCE PROGRAM; INTERFERON-GAMMA IMMUNOTHERAPY; CANDIDA-ALBICANS FILAMENTATION; BLOOD-STREAM INFECTIONS; AMPHOTERICIN-B; ECHINOCANDIN RESISTANCE;

D O I：

10.1111/nyas.13739

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fungal pathogens are a growing threat to public health. As human immunodeficiency becomes increasingly common, fungal infections are becoming more prevalent. The use of antifungal agents for prophylaxis and treatment of fungal infections has favored the emergence of previously rare or unidentified species of drug-resistant fungal pathogens, including several Candida and Cryptococcus species, as well as mold pathogens. As these new and increasingly drug-resistant fungal pathogens continue to emerge, novel strategies for rapid identification and treatment are necessary to combat these life-threatening infections.

引用

收藏

页码：57 / 78

页数：22

相关论文

共 308 条

[1] The epidemiology of hematogenous candidiasis caused by different Candida species [J].

AbiSaid, D ;

Anaissie, E ;

Uzun, O ;

Raad, I ;

Pinzcowski, H ;

Vartivarian, S .

CLINICAL INFECTIOUS DISEASES, 1997, 24 (06) :1122-1128

[2] In vitro combinations of natamycin with voriconazole, itraconazole and micafungin against clinical Fusarium strains causing keratitis [J].

Al-Hatmi, Abdullah M. S. ;

Meletiadis, Joseph ;

Curfs-Breuker, Ilse ;

Bonifaz, Alexandro ;

Meis, Jacques F. ;

De Hoog, G. Sybren .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (04) :953-955

[3] Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for fast and accurate identification of clinically relevant Aspergillus species [J].

Alanio, A. ;

Beretti, J. -L. ;

Dauphin, B. ;

Mellado, E. ;

Quesne, G. ;

Lacroix, C. ;

Amara, A. ;

Berche, P. ;

Nassif, X. ;

Bougnoux, M. -E. .

CLINICAL MICROBIOLOGY AND INFECTION, 2011, 17 (05) :750-755

[4] Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods [J].

Alastruey-Izquierdo, Ana ;

Cuenca-Estrella, Manuel ;

Monzon, Araceli ;

Mellado, Emilia ;

Luis Rodriguez-Tudela, Juan .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 61 (04) :805-809

[5] Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations [J].

Alexander, Barbara D. ;

Johnson, Melissa D. ;

Pfeiffer, Christopher D. ;

Jimenez-Ortigosa, Cristina ;

Catania, Jelena ;

Booker, Rachel ;

Castanheira, Mariana ;

Messer, Shawn A. ;

Perlin, David S. ;

Pfaller, Michael A. .

CLINICAL INFECTIOUS DISEASES, 2013, 56 (12) :1724-1732

[6] Azole antifungals: 35 years of invasive fungal infection management [J].

Allen, David ;

Wilson, Dustin ;

Drew, Richard ;

Perfect, John .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2015, 13 (06) :787-798

[7] Evolution of antifungal-drug resistance: Mechanisms and pathogen fitness [J].

Anderson, JB .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (07) :547-556

[8] Amphotericin forms an extramembranous and fungicidal sterol sponge [J].

Anderson, Thomas M. ;

Clay, Mary C. ;

Cioffi, Alexander G. ;

Diaz, Katrina A. ;

Hisao, Grant S. ;

Tuttle, Marcus D. ;

Nieuwkoop, Andrew J. ;

Comellas, Gemma ;

Maryum, Nashrah ;

Wang, Shu ;

Uno, Brice E. ;

Wildeman, Erin L. ;

Gonen, Tamir ;

Rienstra, Chad M. ;

Burke, Martin D. .

NATURE CHEMICAL BIOLOGY, 2014, 10 (05) :400-U121

[9] Current and future antifungal therapy: new targets for antifungal therapy [J].

Andriole, VT .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (03) :317-321

[10] Stop neglecting fungi [J].

不详 .

NATURE MICROBIOLOGY, 2017, 2 (08)

← 1 2 3 4 5 6 7 8 9 10 →