Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

被引:397
作者
Kajiyama, Sizuo [1 ,2 ]
Hasegawa, Goji [1 ]
Asano, Mai [1 ]
Hosoda, Hiroko [1 ]
Fukui, Michiaki [1 ]
Nakamura, Naoto [1 ]
Kitawaki, Jo [3 ]
Imai, Saeko [2 ,4 ]
Nakano, Koji [5 ]
Ohta, Mitsuhiro [6 ]
Adachi, Tetsuo [7 ]
Obayashi, Hiroshi [8 ]
Yoshikawa, Toshikazu [1 ]
机构
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto 6028566, Japan
[2] Kajiyama Clin, Kyoto 6150035, Japan
[3] Kyoto Prefectural Univ Med, Dept Obstet & Gynecol, Kyoto 6028566, Japan
[4] Osaka Prefecture Univ, Sch Comprehens Rehabil, Osaka 5838555, Japan
[5] Yamashiro Publ Hosp, Kyoto 6190214, Japan
[6] Kobe Pharmaceut Univ, MO, Dept Med Biochem, Kobe, Hyogo 6588566, Japan
[7] Gifu Pharmaceut Univ, Dept Clin Pharmaceut, Gifu 5028585, Japan
[8] Inst Bioresponse Informat, HO, Kyoto 6020845, Japan
关键词
hydrogen-rich water; insulin resistance; type 2 diabetes mellitus; oxidative stress; modified LDL; oxidized LDL; human;
D O I
10.1016/j.nutres.2008.01.008
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Oxidative stress is recognized widely as being associated with various disorders including diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing action. We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We performed a randomized, double-blind, placebo-controlled, crossover study in 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT. The patients consumed either 900 mL/d of hydrogen-rich pure water or 900 mL of placebo pure water for 8 weeks, with a 12-week washout period. Several biomarkers of oxidative stress, insulin resistance, and glucose metabolism, assessed by an oral glucose tolerance test, were evaluated at baseline and at 8 weeks. Intake of hydrogen-rich water was associated with significant decreases in the levels of modified low-density lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15.5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase. In 4 of 6 patients with IGT, intake of hydrogen-rich water normalized the oral glucose tolerance test. In conclusion, these results suggest that supplementation with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:137 / 143
页数:7
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