Cardiorenal disease development under chronic renin-angiotensin-aldosterone system suppression

被引：20
作者：
Sarafidis, Pantelis A. [1 ]
Ruilope, Luis M. [2 ,3 ]
机构：
[1] Kings Coll Hosp London, Acad Dept Renal Med, London, England
[2] Univ Autonoma Madrid, Hypertens Unit, Hosp Octubre 12, Madrid, Spain
[3] Univ Autonoma Madrid, Dept Prevent Med & Publ Hlth, Madrid, Spain
来源：
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2012年 / 13卷 / 01期
关键词：
HEART-FAILURE; DOUBLE-BLIND; MICROALBUMINURIA; INHIBITION; HYPERTENSION; PREVENTION; ONTARGET; BLOCKADE; THERAPY;
D O I：
10.1177/1470320312439140
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Drugs suppressing the renin-angiotensin-aldosterone system (RAAS) are now widely used to treat patients all along the cardiorenal continuum. It supposes that many patients, in particular those with arterial hypertension are treated with converting-enzyme inhibitors and angiotensin receptor blockers for years during which the development and prograssion of cardiorenal disease can be observed. The meaning of this progression in the presence of RAAS suppression requires to be clarified and to be treated in order to diminish the velocity of progression of cardiorenal disease.
引用
收藏
页码：217 / 219
页数：3
相关论文
共 24 条
[1]   Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution? [J].
Athyros, Vasilios G. ;
Mikhailidis, Dimitri P. ;
Kakafika, Anna I. ;
Tziomalos, Konstantinos ;
Karagiannis, Asterios .
EXPERT OPINION ON PHARMACOTHERAPY, 2007, 8 (05) :529-535
[2]   The incidence and implications of aldosterone breakthrough [J].
Bomback, Andrew S. ;
Klemmer, Philip J. .
NATURE CLINICAL PRACTICE NEPHROLOGY, 2007, 3 (09) :486-492
[3]   Microalbuminuria breakthrough under chronic renin-angiotensin-aldosterone system suppression [J].
Cerezo, Cesar ;
Ruilope, Luis M. ;
Segura, Julian ;
Garcia-Donaire, Jose A. ;
de la Cruz, Juan J. ;
Banegas, Jose R. ;
Waeber, Bernard ;
Rabelink, Ton J. ;
Messerli, Franz H. .
JOURNAL OF HYPERTENSION, 2012, 30 (01) :204-209
[4]   How should we manage heart failure developing in patients already treated with angiotensin-converting enzyme inhibitors and beta-blockers for hypertension, diabetes or coronary disease? [J].
Gustafsson, Finn ;
Segura, Julian ;
Ruilope, Luis M. .
JOURNAL OF HYPERTENSION, 2010, 28 (08) :1595-1598
[5]   Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes [J].
Haller, Hermann ;
Ito, Sadayoshi ;
Izzo, Joseph L., Jr. ;
Januszewicz, Andrzej ;
Katayama, Shigehiro ;
Menne, Jan ;
Mimran, Albert ;
Rabelink, Ton J. ;
Ritz, Eberhard ;
Ruilope, Luis M. ;
Rump, Lars C. ;
Viberti, Giancarlo .
NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (10) :907-917
[6]   Meta-analysis: Effect of monotherapy and combination therapy with inhibitors of the renin-angiotensin system on proteinuria in renal disease [J].
Kunz, Regina ;
Friedrich, Chris ;
Wolbers, Marcel ;
Mann, Johannes F. E. .
ANNALS OF INTERNAL MEDICINE, 2008, 148 (01) :30-48
[7]  
Mancia G, 2007, EUR HEART J, V28, P1462, DOI [10.1093/eurheartj/ehm236, 10.1093/eurheartj/eht151]
[8]   Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study):: a multicentre, randomised, double-blind, controlled trial [J].
Mann, Johannes F. E. ;
Schmieder, Roland E. ;
McQueen, Matthew ;
Dyal, Leanne ;
Schumacher, Helmut ;
Pogue, Janice ;
Wang, Xingyu ;
Maggioni, Aldo ;
Budaj, Andrzej ;
Chaithiraphan, Suphachai ;
Dickstein, Kenneth ;
Keltai, Matyas ;
Metsarinne, Kaj ;
Oto, Ali ;
Parkhomenko, Alexander ;
Piegas, Leopoldo S. ;
Svendsen, Tage L. ;
Teo, Koon K. ;
Yusuf, Salim .
LANCET, 2008, 372 (9638) :547-553
[9]   Addition of Angiotensin Receptor Blockade or Mineralocorticoid Antagonism to Maximal Angiotensin-Converting Enzyme Inhibition in Diabetic Nephropathy [J].
Mehdi, Uzma F. ;
Adams-Huet, Beverley ;
Raskin, Philip ;
Vega, Gloria L. ;
Toto, Robert D. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (12) :2641-2650
[10]   Aliskiren combined with losartan in type 2 diabetes and nephropathy [J].
Parving, Hans-Henrik ;
Persson, Frederik ;
Lewis, Julia B. ;
Lewis, Edmund J. ;
Hollenberg, Norman K. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (23) :2433-2446
123