Significance of EGFR Expression in Circulating Tumor Cells

被引：8

作者：

Jose Serrano, Maria ^{[1
,2
]}

Jesus Alvarez-Cubero, Maria ^{[1
]}

De Miguel Perez, Diego ^{[1
,3
]}

Rodriguez-Martinez, Alba ^{[1
,3
]}

Gonzalez-Herrera, Lucas ^{[1
,3
]}

Robles-Fernandez, Inmaculada ^{[1
]}

Exposito Hernandez, Jose ^{[2
]}

Garcia Puche, Jose Luis ^{[1
]}

Antonio Lorente, Jose ^{[1
,3
]}

机构：

[1] Univ Granada, GENYO, Ctr Genom & Oncol Res, Andalusian Reg Govt,Pfizer, PTS Granada Av Ilustrat 114, Granada 18016, Spain

[2] Clin Univ Hosp, Integral Oncol Div, Av Dr Oloriz 16, Granada 18012, Spain

[3] Univ Granada, Dept Forens Med, Fac Med, Av Invest, Granada 18071, Spain

来源：

ISOLATION AND MOLECULAR CHARACTERIZATION OF CIRCULATING TUMOR CELLS | 2017年 / 994卷

关键词：

Circulating tumor cells (CTCs); Dormancy; Epidermal growth factor receptor (EGFR); Epithelial mesenchymal transition (EMT); Invasion; Mutations; Migration; Resistant clones; DOWN-REGULATION; UROKINASE RECEPTOR; CANCER METASTASIS; GROWTH; INVASION; MECHANISMS; CARCINOMA; DORMANCY; ACTIVATION; MIGRATION;

D O I：

10.1007/978-3-319-55947-6_16

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This chapter focuses on a deep description of the epidermal growth factor receptor (EGFR) expression in circulating tumor cells (CTCs) and its main role in cancer progression, genetic changes related to metastasis, and resistance to treatment. The aberrant behavior of cancer cells is caused by genetic mutations and altered patterns of gene expression. These changes can be responsible for an increase in cell motility but also an ability of CTCs to survival in different microenvironments, as well as developing therapy-resistant clones. Finally, CTCs can acquire the ability to invade distant organs, where metastatic foci can develop.

引用

页码：285 / 296

页数：12

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