blaKPC RNA Expression Correlates with Two Transcriptional Start Sites but Not Always with Gene Copy Number in Four Genera of Gram-Negative Pathogens

被引：22

作者：

Roth, Amanda L. ^{[1
]}

Kurpiel, Philip M. ^{[1
]}

Lister, Philip D. ^{[1
]}

Hanson, Nancy D. ^{[1
]}

机构：

[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Ctr Res Antiinfect & Biotechnol, Omaha, NE 68178 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 08期

关键词：

NEW-YORK-CITY; HYDROLYZING BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; CARBAPENEM RESISTANCE; KPC-2; SUSCEPTIBILITY; EMERGENCE; PCR;

D O I：

10.1128/AAC.01509-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Klebsiella pneumoniae carbapenemase (KPC)-producing organisms are therapeutically and diagnostically challenging. It is possible that bla(KPC) gene expression plays a role in the variability observed in clinical susceptibility testing. bla(KPC) transformants together with 10 clinical isolates representing four genera were evaluated for bla(KPC) copy number and gene expression and correlated with beta-lactam MIC data. The data suggest that mechanisms other than gene copy number and expression of bla(KPC) contribute to variability in susceptibility when testing KPC-producing isolates.

引用

收藏

页码：3936 / 3938

页数：3

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