Comparison of volatile organic compound profiles in exhaled breath versus plasma headspace in different diseases

被引:6
作者
Grove, David [1 ]
Miller-Atkins, Galen [2 ]
Melillo, Celia [1 ]
Rieder, Florian [3 ,4 ,5 ]
Kurada, Satya [3 ,4 ,5 ]
Rotroff, Daniel M. [2 ]
Tonelli, Adriano R. [1 ,6 ,7 ,8 ]
Dweik, Raed A. [1 ,6 ,7 ,8 ]
机构
[1] Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44106 USA
[2] Cleveland Clin, Lerner Res Inst, Dept Quantitat Hlth Sci, Cleveland, OH 44106 USA
[3] Cleveland Clin, Digest Dis & Surg Inst, Dept Gastroenterol, Cleveland, OH 44106 USA
[4] Cleveland Clin, Digest Dis & Surg Inst, Dept Hepatol, Cleveland, OH 44106 USA
[5] Cleveland Clin, Digest Dis & Surg Inst, Dept Nutr, Cleveland, OH 44106 USA
[6] Cleveland Clin, Resp Inst, Dept Pulm, Cleveland, OH 44106 USA
[7] Cleveland Clin, Resp Inst, Dept Allergy, Cleveland, OH 44106 USA
[8] Cleveland Clin, Resp Inst, Dept Crit Care Med, Cleveland, OH 44106 USA
关键词
breath analysis; exhaled breath; volatile organic compounds; plasma headspace; SIFT-MS; MASS-SPECTROMETRY; AIR;
D O I
10.1088/1752-7163/ab8866
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Breath analysis is the study of volatile organic compounds (VOC's) in exhaled breath. This analysis provides information on the body's condition. In this study we investigated the relationship between 22 VOC's detected in exhaled breath and plasma headspace using a selected ion flow tube mass spectrometer (SYFT-MS). We compared pairs of exhaled breath and plasma samples from patients with pulmonary hypertension inflammatory bowel disease (IBD), and IBD patients after J-pouch surgery (pouch group). Half of the measured VOC's from exhaled breath were significantly associated with the VOC's from plasma headspace. Interestingly, six breath VOC's (trimethyl amine (FDR p = 0.02), hydrogen sulfide (FDR p = 7.64 x 10(-30)), ethanol (FDR p = 1.56 x 10(-4)), dimethyl sulfide (FDR p = 5.70 x 10(-19)), benzene (FDR p = 8.40 x 10(-27)), and acetaldehyde (FDR p = 4.27 x 10(-17))) and two plasma headspace VOC's (1-Octene (FDR p = 0.02) and 2-propanol (FDR p = 2.47 x 10(-9))) were able to differentiate between the three groups. Breath and plasma headspace share a similar signature with significant association in half of the measured VOCs. The disease discriminatory capacity of breath and plasma headspace appear to be different. Therefore, using the VOC's print from both breath and plasma headspace may better help diagnose patients.
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页数:8
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