Mechanism of SARS-CoV-2 Invasion into the Liver and Hepatic Injury in Patients with COVID-19

被引：23

作者：

Zhang, XiaoTian ^{[1
]}

Yu, Yanhui ^{[1
]}

Zhang, Chao ^{[2
]}

Wang, Hongrui ^{[3
]}

Zhao, Lijuan ^{[3
]}

Wang, Hua ^{[3
]}

Su, Yingying ^{[4
]}

Yang, Ming ^{[3
]}

机构：

[1] Jilin Univ, Dept Clin Lab, Hosp 2, Changchun, Jilin, Peoples R China

[2] Jilin Univ, Dept Nucl Med, Hosp 2, Changchun, Jilin, Peoples R China

[3] Jilin Univ, Coll Basic Med Sci, Dept Mol Biol, 126 Xinmin St, Changchun 130021, Jilin, Peoples R China

[4] Jilin Univ, Dept Anat, Coll Basic Med Sci, Jilin, Jilin, Peoples R China

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2022年 / 14卷

关键词：

SARS-CoV-2; COVID-19; Liver injury; Viral invasion; Biochemical indicator; CLINICAL CHARACTERISTICS; CORONAVIRUS; EXPRESSION; INFECTION; DISEASE; ACE2; PATHOGENESIS; PNEUMONIA; RECEPTOR; WUHAN;

D O I：

10.4084/MJHID.2022.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many studies have shown that patients with Coronavirus disease 2019 (COVID-19) have different degrees of liver injury. However, the mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invasion into the liver are still not fully understood. This review mainly summarizes the recently published works on the abnormal liver biochemical indicators and the mechanism of viral invasion with liver injury in COVID-19 patients. Generally, SARS-CoV-2 infection of the liver was caused by blood circulation or retrograde infection of the digestive tract, which led to the liver injury through direct cytopathic effect induced by virus or immunopathological effect caused by excessive inflammation. Besides these, hypoxia, endothelial injury and drug-induced jury were also the main reasons of liver injury in COVID-19 patients. In the liver function indicators, elevated alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, and lactate dehydrogenase levels with reduced albumin levels were observed in COVID-19 patients.

引用

页数：11

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