Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella

被引：50

作者：

Gunasekera, SP

McCarthy, PJ

Longley, RE

Pomponi, SA

Wright, AE

Lobkovsky, E

Clardy, J

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

[2] Cornell Univ, Baker Lab, Dept Chem, Ithaca, NY 14853 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980293y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Discorhabdin P (1), a new discorhabdin analogue, has been isolated from a deep-water marine sponge of the genus Batzella. Discorhabdin P (1) inhibited the phosphatase activity of calcineurin and the peptidase activity of CPP32. It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described.

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页码：173 / 175

页数：3

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