In vitro Amoebicidal Activity of Borage (Borago officinalis) Extract on Entamoeba histolytica

被引:9
|
作者
Leos-Rivas, Catalina [3 ]
Julia Verde-Star, M. [3 ]
Osuna Torres, Lidia [2 ]
Oranday-Cardenas, Azucena [3 ]
Rivas-Morales, Catalina [3 ]
Porfiria Barron-Gonzalez, M. [3 ]
Morales-Vallarta, Mario R. [3 ]
Cruz-Vega, Delia E. [1 ]
机构
[1] CITES, Escuela Med, ITESM, Monterrey 64710, NL, Mexico
[2] Ctr Invest Biomed Sur, Xochitepec Morelos, Mexico
[3] Univ Autonoma Nuevo Leon, Fac Biol Sci, San Nicolas De Los Garza, Nuevo Leon, Mexico
关键词
Boraginaceae; brine shrimp; cytotoxicity; traditional medicine; METRONIDAZOLE RESISTANCE; ANTIPROTOZOAL ACTIVITY; SUPEROXIDE-DISMUTASE; MEDICINAL-PLANTS;
D O I
10.1089/jmf.2010.0164
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC50) of the extract for Entamoeba histolytica was 33 mu g/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 mu g/mL. The IC50 of the extract for Vero cells was 203.9 mu g/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.
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页码:866 / 869
页数:4
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