In vitro Amoebicidal Activity of Borage (Borago officinalis) Extract on Entamoeba histolytica

被引：9

作者：

Leos-Rivas, Catalina ^{[3
]}

Julia Verde-Star, M. ^{[3
]}

Osuna Torres, Lidia ^{[2
]}

Oranday-Cardenas, Azucena ^{[3
]}

Rivas-Morales, Catalina ^{[3
]}

Porfiria Barron-Gonzalez, M. ^{[3
]}

Morales-Vallarta, Mario R. ^{[3
]}

Cruz-Vega, Delia E. ^{[1
]}

机构：

[1] CITES, Escuela Med, ITESM, Monterrey 64710, NL, Mexico

[2] Ctr Invest Biomed Sur, Xochitepec Morelos, Mexico

[3] Univ Autonoma Nuevo Leon, Fac Biol Sci, San Nicolas De Los Garza, Nuevo Leon, Mexico

来源：

JOURNAL OF MEDICINAL FOOD | 2011年 / 14卷 / 7-8期

关键词：

Boraginaceae; brine shrimp; cytotoxicity; traditional medicine; METRONIDAZOLE RESISTANCE; ANTIPROTOZOAL ACTIVITY; SUPEROXIDE-DISMUTASE; MEDICINAL-PLANTS;

D O I：

10.1089/jmf.2010.0164

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC50) of the extract for Entamoeba histolytica was 33 mu g/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 mu g/mL. The IC50 of the extract for Vero cells was 203.9 mu g/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.

引用

页码：866 / 869

页数：4

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