Proton pump inhibitors: Review of reported risks and controversies

被引：26

作者：

Brisebois, Simon ^{[1
]}

Merati, Albert ^{[1
]}

Giliberto, John Paul ^{[2
]}

机构：

[1] Univ Washington, Dept Otolaryngol Head & Neck Surg, Seattle, WA 98195 USA

[2] Univ Cincinnati, Dept Otolaryngol Head & Neck Surg, Coll Med, Cincinnati, OH USA

来源：

LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY | 2018年 / 3卷 / 06期

关键词：

Proton Pump Inhibitors risks; laryngopharyngeal reflux; gastroesophageal reflux disease; BONE-MINERAL DENSITY; RECEPTOR ANTAGONIST USE; REFLUX; ACID; OSTEOPOROSIS; METAANALYSIS; ASSOCIATION; PREVALENCE; OMEPRAZOLE; FRACTURES;

D O I：

10.1002/lio2.187

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Proton pump inhibitors (PPIs) are among the most prescribed classes of drugs in this day and age. These may be beneficial to treat many gastrointestinal conditions, such as gastroesophageal reflux or Barrett's esophagus as well as laryngopharyngeal reflux. However, many reports have emerged in the literature exposing the potential association of PPIs with various risks and complications such as bone fracture, infection, myocardial infarction, renal disease, and dementia. This review highlights many of these potential adverse side effects by exploring relevant publications and addressing the controversies associated with those findings. The diligent otolaryngologist should be aware of the current state of the literature and the risks associated with prescribing PPIs to insure proper counseling of their patients. Level of Evidence 5

引用

页码：457 / 462

页数：6

共 46 条

[1] Systematic review: the use of proton pump inhibitors and increased susceptibility to enteric infection [J].

Bavishi, C. ;

DuPont, H. L. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 34 (11-12) :1269-1281

[2] Clopidogrel with or without Omeprazole in Coronary Artery Disease. [J].

Bhatt, Deepak L. ;

Cryer, Byron L. ;

Contant, Charles F. ;

Cohen, Marc ;

Lanas, Angel ;

Schnitzer, Thomas J. ;

Shook, Thomas L. ;

Lapuerta, Pablo ;

Goldsmith, Mark A. ;

Laine, Loren ;

Scirica, Benjamin M. ;

Murphy, Sabina A. ;

Cannon, Christopher P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (20) :1909-1917

[3] Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies [J].

Cheungpasitporn, Wisit ;

Thongprayoon, Charat ;

Kittanamongkolchai, Wonngarm ;

Srivali, Narat ;

Edmonds, Peter J. ;

Ungprasert, Patompong ;

O'Corragain, Oisin A. ;

Korpaisarn, Sira ;

Erickson, Stephen B. .

RENAL FAILURE, 2015, 37 (07) :1237-1241

[4] Subnormal vitamin B12 concentrations and anaemia in older people: a systematic review [J].

den Elzen, Wendy P. J. ;

van der Weele, Gerda M. ;

Gussekloo, Jacobijn ;

Westendorp, Rudi G. J. ;

Assendelft, Willem J. J. .

BMC GERIATRICS, 2010, 10

[5] Do acid-lowering agents affect vitamin B12 status in older adults? [J].

Dhamiarajan, T. S. ;

Kanagala, Madhusudhana R. ;

Murakonda, Padrnavathi ;

Lebelt, Ahna S. ;

Norkus, Edward P. .

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2008, 9 (03) :162-167

[6] Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis [J].

Eom, Chun-Sick ;

Jeon, Christie Y. ;

Lim, Ju-Won ;

Cho, Eun-Geol ;

Park, Sang Min ;

Lee, Kang-Sook .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2011, 183 (03) :310-319

[7] Use of proton pump inhibitors is associated with fractures in young adults: a population-based study [J].

Freedberg, D. E. ;

Haynes, K. ;

Denburg, M. R. ;

Zemel, B. S. ;

Leonard, M. B. ;

Abrams, J. A. ;

Yang, Y. -X. .

OSTEOPOROSIS INTERNATIONAL, 2015, 26 (10) :2501-2507

[8] The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association [J].

Freedberg, Daniel E. ;

Kim, Lawrence S. ;

Yang, Yu-Xiao .

GASTROENTEROLOGY, 2017, 152 (04) :706-715

[9] The Accuracy of the Laryngopharyngeal Reflux Diagnosis: Utility of the Stroboscopic Exam [J].

Fritz, Mark A. ;

Persky, Michael J. ;

Fang, Yixin ;

Simpson, C. Blake ;

Amin, Milan R. ;

Akst, Lee M. ;

Postma, Gregory N. .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2016, 155 (04) :629-634

[10] Use of acid-suppressing drugs and the risk of bacterial gastroenteritis [J].

Garcia Rodriguez, Luis Alberto ;

Ruigomez, Ana ;

Panes, Julian .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (12) :1418-1423

← 1 2 3 4 5 →