AML Therapy: Wake Up the Guardian and Cut Loose the Executioners

被引：6

作者：

Altieri, Dario C. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Immunol Microenvironm & Metastasis Program, 3601 Spruce St, Philadelphia, PA 19104 USA

来源：

CANCER CELL | 2017年 / 32卷 / 06期

关键词：

ACUTE MYELOID-LEUKEMIA; APOPTOSIS;

D O I：

10.1016/j.ccell.2017.11.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Pan et al. show that a combination therapy designed to reactivate the p53 tumor suppressor while antagonizing the anti-apoptotic function of Bcl-2 is highly active in preclinical models of refractory acute myeloid leukemia (AML). The results may move the needle in this hard-to-treat malignancy.

引用

页码：719 / 720

页数：2

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