Re: Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS Exon 19 deletion is not detected by the real-time PCR IdyllaTM EGFR mutation test but is detected by ctDNA NGS and responds to osimertinib

被引：2

作者：

Bennett, Phil ^{[1
]}

Finall, Alison ^{[2
]}

Medeiros, Filomena ^{[3
]}

Gerrard, Gareth ^{[4
]}

Taniere, Phillipe ^{[5
]}

机构：

[1] HCA Healthcare UK, Sarah Cannon Mol Diagnost, London, England

[2] Swansea Bay Univ Hlth Board, Cellular Pathol, Swansea, W Glam, Wales

[3] Mid & South Essex NHS Fdn Trust, Cardiothorac Pathol, Basildon, England

[4] Guys & St Thomas NHS Fdn Trust, Canc Genet, London, England

[5] NHS Fdn Trust, Univ Hosp Birmingham, Mol Pathol Diagnost Serv, Birmingham, England

来源：

EUROPEAN JOURNAL OF CANCER | 2022年 / 174卷

关键词：

D O I：

10.1016/j.ejca.2022.06.039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：315 / 317

页数：3

共 6 条

[1]

Finall A, 2021, J CLIN PATHOL

[2] Performance evaluation of the Biocartis Idylla EGFR Mutation Test using pre-extracted DNA from a cohort of highly characterised mutation positive samples [J].

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JOURNAL OF CLINICAL PATHOLOGY, 2022, 75 (04) :241-249

[3] Is the current strategy for stratifying patients for targeted therapy use in NSCLC really logical and sustainable? Results from a retrospective study suggest otherwise [J].

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[4] Prevalence and breakdown of EGFR exon 20 driver mutations in routine NHS lung cancer diagnostic testing [J].

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JOURNAL OF CLINICAL PATHOLOGY, 2022, 75 (03) :209-210

[5] Analysis of a large cohort of non-small cell lung cancers submitted for somatic variant analysis demonstrates that targeted next-generation sequencing is fit for purpose as a molecular diagnostic assay in routine practice [J].

Moore, David Allan ;

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Ingham, Alexander ;

Arkenau, Hendrik-Tobias ;

Bennett, Philip .

JOURNAL OF CLINICAL PATHOLOGY, 2018, 71 (11) :1001-1006

[6] Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib [J].

O'Sullivan, Hazel ;

d'Arienzo, Paolo D. ;

Yousaf, Nadia ;

Cui, Wanyuan ;

Popat, Sanjay .

EUROPEAN JOURNAL OF CANCER, 2022, 166 :38-40

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