Nonrecurring Circuit Nanozymatic Enhancement of Hypoxic Pancreatic Cancer Phototherapy Using Speckled Ru-Te Hollow Nanorods

被引：63

作者：

Kang, Seounghun ^{[1
,2
]}

Gil, Yeong-Gyu ^{[4
]}

Min, Dal-Hee ^{[1
,2
,3
]}

Jang, Hongje ^{[4
]}

机构：

[1] Seoul Natl Univ, Dept Chem, IBS, Seoul 08826, South Korea

[2] Seoul Natl Univ, Ctr RNA Res, IBS, Seoul 08826, South Korea

[3] Lemonex Inc, Inst Biotherapeut Convergence Technol, Seoul 08826, South Korea

[4] Kwangwoon Univ, Dept Chem, Seoul 01897, South Korea

来源：

ACS NANO | 2020年 / 14卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

galvanic replacement; nanozyme; hypoxia; phototherapy; ruthenium; PHOTODYNAMIC THERAPY; O-2-EVOLVING NANOPARTICLES; GALVANIC REPLACEMENT; METAL NANOSTRUCTURES; HIF-ALPHA; EFFICIENT; PEROXIDASE; RESISTANCE;

D O I：

10.1021/acsnano.9b09974

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanozymatic reactions that produce or consume oxygen (O-2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity. Although extensive studies were conducted to overcome hypoxia through nanozymatic reactions, the construction of an ideal system is challenging, given that the reactants and products are arranged in a recurring structure for continuous consumption in a full cycle. In this study, speckled Ru-Te hollow nanorods were prepared through solvothermal galvanic replacement against Te nanorod templates with high yield and robustness. From their multicompositional characteristics, nonrecurring peroxidase-SOD-catalase-type nanozymatic properties were identified with photothermal and photodynamic feasibility over a wide range of laser irradiation wavelengths. Owing to the excellent colloidal stability and biocompatibility, the proposed Ru-Te-based nanozymatic platform was highly effective in hypoxic pancreatic cancer phototherapy in vitro and in vivo by near-infrared laser irradiation mediated photothermal and photodynamic combination treatment.

引用

页码：4383 / 4394

页数：12

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