The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer

被引：73

作者：

Fan, Yiqi ^{[1
]}

He, Shuai ^{[1
]}

机构：

[1] Southern Med Univ, Zhujiang Hosp, Dept Pharm, Guangzhou 510282, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2022年 / 14卷

关键词：

triple negative breast cancer; microenvironment; immune cells; immunotherapy; INDUCED KILLER-CELLS; INFILTRATING LYMPHOCYTES; T-CELLS; ADJUVANT CHEMOTHERAPY; PD-L1; EXPRESSION; PREDICTIVE-VALUE; CIK CELLS; IFN-GAMMA; MACROPHAGES; IMMUNOTHERAPY;

D O I：

10.2147/CMAR.S316700

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for 10-20% of breast cancers with high intrinsic heterogeneity. Its unique immune microenvironment, including high expression of vascular endothelial growth factors, tumor infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and other molecules that promote the growth and migration of tumor cells, has been shown to play a dual role in the occurrence, growth, and metastasis of TNBC. Understanding the TNBC microenvironment is of great significance for the prognosis and treatment of TNBC. In this article, we describe the composition and function of immune cells in the TNBC microenvironment and summarize the major cytokine growth factors and chemokines in the TNBC microenvironment. Finally, we discuss the progress of TNBC, cytokine-induced killer cell therapy, and immune checkpoint therapy.

引用

页码：1 / 17

页数：17

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