Sex Differences in Drug Disposition

被引：229

作者：

Soldin, Offie P. ^{[1
,2
,3
,4
,5
]}

Chung, Sarah H. ^{[1
]}

Mattison, Donald R. ^{[6
]}

机构：

[1] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20057 USA

[2] Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20057 USA

[3] Georgetown Univ, Med Ctr, Dept Physiol, Washington, DC 20057 USA

[4] Georgetown Univ, Med Ctr, Dept Obstet & Gynecol, Washington, DC 20057 USA

[5] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, LL, Washington, DC 20057 USA

[6] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Rockville, MD 20852 USA

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

MENSTRUAL-CYCLE; BODY-WEIGHT; OCCUPATIONAL-HEALTH; CYTOCHROME-P450; 3A4; ANTIDIABETIC DRUGS; GENDER; PHARMACOKINETICS; AGE; WOMEN; RECEPTOR;

D O I：

10.1155/2011/187103

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Physiological, hormonal, and genetic differences between males and females affect the prevalence, incidence, and severity of diseases and responses to therapy. Understanding these differences is important for designing safe and effective treatments. This paper summarizes sex differences that impact drug disposition and includes a general comparison of clinical pharmacology as it applies to men and women.

引用

页数：14

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