Associations of Genes for Killer Cell Immunoglobulin-like Receptors and Their Human Leukocyte Antigen-A/B/C Ligands with Abdominal Aortic Aneurysm

被引:4
作者
Dubis, Joanna [1 ]
Niepieklo-Miniewska, Wanda [2 ]
Jedruchniewicz, Natalia [1 ]
Sobczynski, Maciej [3 ]
Witkiewicz, Wojciech [4 ]
Zapotoczny, Norbert [4 ]
Kusnierczyk, Piotr [2 ]
机构
[1] Reg Specialist Hosp, Ctr Res & Dev, PL-51124 Wroclaw, Poland
[2] Polish Acad Sci, Lab Immunogenet & Tissue Immunol, Hirszfeld Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland
[3] Polish Acad Sci, Nencki Inst Expt Biol, Lab Mol Neurobiol, PL-02093 Warsaw, Poland
[4] Reg Specialist Hosp Wroclaw, Dept Vasc Surg, PL-51124 Wroclaw, Poland
关键词
abdominal aortic aneurism; genetics; KIR; HLA; immune cells; aneurysm diameter; CAD; BMI; HLA; DISEASE; ALLELE; KIR; AUTOIMMUNITY; POLYMORPHISM; EDUCATION;
D O I
10.3390/cells10123357
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Abdominal aortic aneurysm (AAA) is an immune-mediated disease with a genetic component. The multifactorial pathophysiology is not clear and there is still no pharmacotherapy to slow the growth of aneurysms. The signal integration of cell-surface KIRs (killer cell immunoglobulin-like receptors) with HLA (ligands, human leukocyte class I antigen molecules) modulates the activity of natural killer immune cells. The genetic diversity of the KIR/HLA system is associated with the risk of immune disorders. This study was a multivariate analysis of the association between genetic variants of KIRs, HLA ligands, clinical data and AAA formation. Genotyping was performed by single polymerase chain reaction with sequence-specific primers using commercial assays. Patients with HLA-A-Bw4 have a larger aneurysm by an average of 4 mm (p = 0.008). We observed a relationship between aneurysm diameter and BMI in patients with AAA and co-existing CAD; its shape was determined by the presence of HLA-A-Bw4. There was also a nearly 10% difference in KIR3DL1 allele frequency between the study and control groups. High expression of the cell surface receptor KIR3DL1 may protect, to some extent, against AAA. The presence of HLA-A-Bw4 may affect the rate of aneurysm growth and represents a potential regional pathogenetic risk of autoimmune injury to the aneurysmal aorta.
引用
收藏
页数:16
相关论文
共 49 条
[1]   Risk Factors for Abdominal Aortic Aneurysm in Population-Based Studies: A Systematic Review and Meta-Analysis [J].
Altobelli, Emma ;
Rapacchietta, Leonardo ;
Profeta, Valerio F. ;
Fagnano, Roberto .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2018, 15 (12)
[2]   Genetic polymorphism of HLA-DRB1 alleles in Mexican mestizo patients with abdominal aortic aneurysms [J].
Anaya-Ayala, Javier E. ;
Hernandez-Dono, Susana ;
Escamilla-Tilch, Monica ;
Marquez-Garcia, Jose ;
Hernandez-Sotelo, Kemberly ;
Lozano-Corona, Rodrigo ;
Ruiz-Gomez, Daniela ;
Granados, Julio ;
Hinojosa, Carlos A. .
BMC MEDICAL GENETICS, 2019, 20
[3]   Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease [J].
Anderson, Kirsten M. ;
Augusto, Danillo G. ;
Dandekar, Ravi ;
Shams, Hengameh ;
Zhao, Chao ;
Yusufali, Tasneem ;
Montero-Martin, Gonzalo ;
Marin, Wesley M. ;
Nemat-Gorgani, Neda ;
Creary, Lisa E. ;
Caillier, Stacy ;
Mofrad, Mohammad R. K. ;
Parham, Peter ;
Fernandez-Vina, Marcelo ;
Oksenberg, Jorge R. ;
Norman, Paul J. ;
Hollenbach, Jill A. .
JOURNAL OF IMMUNOLOGY, 2020, 205 (05) :1323-1330
[4]   Biomechanical factors in the biology of aortic wall and aortic valve diseases [J].
Back, Magnus ;
Gasser, T. Christian ;
Michel, Jean-Baptiste ;
Caligiuri, Giuseppina .
CARDIOVASCULAR RESEARCH, 2013, 99 (02) :232-241
[5]   The role of human leukocyte antigen genes in the formation of abdominal aortic aneurysms [J].
Badger, Stephen A. ;
Soong, Chee V. ;
O'Donnell, Mark E. ;
Middleton, Derek .
JOURNAL OF VASCULAR SURGERY, 2007, 45 (03) :475-480
[6]   Natural killer cell education in human health and disease [J].
Boudreau, Jeanette E. ;
Hsu, Katharine C. .
CURRENT OPINION IN IMMUNOLOGY, 2018, 50 :102-111
[7]   Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease [J].
Castano-Nunez, Angel ;
Montes-Cano, Marco-Antonio ;
Garcia-Lozano, Jose-Raul ;
Ortego-Centeno, Norberto ;
Garcia-Hernandez, Francisco-Jose ;
Espinosa, Gerard ;
Grana-Gil, Genaro ;
Sanchez-Burson, Juan ;
Julia, Maria-Rosa ;
Solans, Roser ;
Blanco, Ricardo ;
Barnosi-Marin, Ana-Celia ;
Gomez de la Torre, Ricardo ;
Fanlo, Patricia ;
Rodriguez-Carballeira, Monica ;
Rodriguez-Rodriguez, Luis ;
Camps, Teresa ;
Castaneda, Santos ;
Alegre-Sancho, Juan-Jose ;
Martin, Javier ;
Gonzalez-Escribano, Maria-Francisca .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[8]   Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT, and helper T cells [J].
Chan, WL ;
Pejnovic, N ;
Hamilton, H ;
Liew, TV ;
Popadic, D ;
Poggi, A ;
Khan, SM .
CIRCULATION RESEARCH, 2005, 96 (06) :675-683
[9]   Exploring autoimmunity in the pathogenesis of abdominal aortic aneurysms [J].
Chang, Tiffany W. ;
Gracon, Adam S. A. ;
Murphy, Michael P. ;
Wilkes, David S. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2015, 309 (05) :H719-H727
[10]   The association of obesity with abdominal aortic aneurysm presence and growth [J].
Cronin, Oliver ;
Walker, Philip J. ;
Golledge, Jonathan .
ATHEROSCLEROSIS, 2013, 226 (02) :321-327