Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles for two-photon photodynamic therapy or photoacoustic imaging

被引：35

作者：

Mauriello-Jimenez, Chiara ^{[1
]}

Henry, Maxime ^{[2
,3
]}

Aggad, Dina ^{[4
]}

Raehm, Laurence ^{[1
]}

Cattoen, Xavier ^{[5
]}

Man, Michel Wong Chi ^{[1
]}

Charnay, Clarence ^{[1
]}

Alpugan, Serkan ^{[6
]}

Ahsen, Vefa ^{[6
]}

Tarakci, Deniz Kutlu ^{[6
]}

Maillard, Philippe ^{[7
]}

Maynadier, Marie ^{[8
]}

Garcia, Marcel ^{[4
]}

Dumoulin, Fabienne ^{[6
]}

Gary-Bobo, Magali ^{[4
]}

Coll, Jean-Luc ^{[2
,3
]}

Josserand, Veronique ^{[2
,3
]}

Durand, Jean-Olivier ^{[1
]}

机构：

[1] UM, Inst Charles Gerhardt Montpellier, ENSCM, CNRS,UMR 5253, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France

[2] Inst Adv Biosci, INSERM, U1209, F-38000 Grenoble, France

[3] Univ Grenoble Alpes, Inst Adv Biosci, F-38000 Grenoble, France

[4] Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, Ave Charles Flahault, F-34093 Montpellier 05, France

[5] UGA, Inst NEEL, CNRS, UPR2940, 25 Rue Martyrs BP 166, F-38042 Grenoble 9, France

[6] Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kocaeli, Turkey

[7] Inst CURIE Rech, CNRS, UMR 9187, Unite CMIB,INSERM,U1196,Ctr Univ, Bat 110-112,Rue H Becquerel, F-91405 Orsay, France

[8] NanoMedSyn, Fac Pharm, Ave Charles Flahault, F-34093 Montpellier 05, France

来源：

NANOSCALE | 2017年 / 9卷 / 43期

关键词：

SILICA NANOPARTICLES; GOLD NANOROD; FLUORESCENCE; NANOMATERIALS; ABSORPTION; AGENTS;

D O I：

10.1039/c7nr04677d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.

引用

收藏

页码：16622 / 16626

页数：5

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