Polysaccharide from Patinopecten yessoensis Skirt Boosts Immune Response via Modulation of Gut Microbiota and Short-Chain Fatty Acids Metabolism in Mice

被引:9
作者
Li, Ying [1 ,2 ,3 ,4 ]
Qin, Juan [1 ]
Cheng, Yinghui [1 ]
Ai, Yuqing [1 ]
Han, Zhiyi [1 ]
Li, Meng [1 ,2 ,4 ,5 ]
Qi, Yanxia [1 ,2 ,3 ]
Zhao, Qiancheng [1 ,2 ,3 ,4 ]
Li, Zhibo [5 ]
机构
[1] Dalian Ocean Univ, Coll Food Sci & Engn, Dalian 116023, Peoples R China
[2] Dalian Ocean Univ, Dalian Key Lab Marine Bioact Subst Dev & High Val, Dalian 116023, Peoples R China
[3] Dalian Ocean Univ, Testing & Proc Technol Sci Serv Ctr, Liaoning Prov Aquat Prod Analyzing, Dalian 116023, Peoples R China
[4] Dalian Polytech Univ, Collaborat Innovat Ctr Prov & Ministerial Coconst, Dalian 116034, Peoples R China
[5] Dalian Ocean Univ, Key Lab Aquat Prod Proc & Utilizat Liaoning Prov, Dalian 116023, Peoples R China
关键词
polysaccharides; scallop skirt; gut microbiota; short-chain fatty acids; immune response; SULFATED POLYSACCHARIDES; ANTITUMOR-ACTIVITY; FERMENTATION; ACTIVATION; DYSBIOSIS;
D O I
10.3390/foods10102478
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Polysaccharide from marine shellfish has various bioactivities. In this study, the effects of polysaccharide from Patinopecten yessoensis skirt (PS) on boosting immune response in mice were evaluated, and the potential mechanisms were explored. The results showed that PS administration effectively increased the serum IgG and IgM levels, implying that PS had immune response-boosting properties. Moreover, PS administration could modulate the composition of the gut microbiota, and significantly improve short-chain fatty acids (SCFAs) metabolism, especially butyrate metabolism. Of note, the expression of the Tlr2, Tlr7, MyD88, Tnfa, and Il1b genes in toll-like receptor (TLR) signaling pathway was significantly increased. In summary, PS could boost immune response by modulating the gut microbiota and SCFAs metabolism correlating with the activation of the TLR signaling pathway. Therefore, PS can be developed as a special ingredient for functional product.
引用
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页数:15
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