A novel template for non-peptide CCR5 receptor antagonists

被引：0

作者：

不详

机构：

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2001年 / 11卷 / 04期

关键词：

CCR5; antagonist; chemokine; HIV-1; inflammation; RANTES; rheumatoid arthritis;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent non-peptide chemokine CCR5 receptor antagonists have been identified, based upon a 1(1-aroylpiperidin-4-yl)piperidine template previously employed in a series of muscarinic M-2 receptor antagonists. Two applications claim piperidinylpiperidine and piperidinylpiperazine derivatives, respectively, including compounds with low nanomolar affinity for the CCR5 receptor. Such compounds are claimed to be useful in the treatment of HIV infection and inflammatory diseases.

引用

页码：697 / 700

页数：4

共 8 条

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