Antidepressant use and expenditure in the treatment of patients with depression: Evidence from China urban medical claims data

Objectives: Few studies have analyzed the use of antidepressants among population suffering from depression in China. This study aimed to describe the prevalence and the cost of commonly prescribed antidepressants among patients with depression. Methods: This study used data that comprised 5% random sample of claims data from China's Urban Basic Medical Insurance between 2013 and 2016. We estimated the prevalence, calculated the proportions of those on antidepressant treatment as well as those on specific drugs. Results: Among 26 826 patients with depression, 62.31% were prescribed with antidepressants in urban China, and the estimated average annual total cost of antidepressants per patient was RMB887.7(USD140.9). The prevalence of antidepressant prescription was higher among patients aged 15-24 years, having URBMI insurance, with recurrent depression and having severe or moderate depression. Approximately 9.3% of patients used more than one type of antidepressants and 19% of patients have only one prescription of antidepressant in a year. Conclusion: Our analyses showed that antidepressant prescribing was prevalent among patients with depression, particularly in adolescents and youth groups, and are subject to variation with clinical features and different insurance scheme. Further investigation of antidepressant use patterns, such as duration, combination and switching, as well as treatment trajectories will facilitate our understanding of the pharmacotherapy practices of depressive disorders.