Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats

被引：59

作者：

Hao, Y ^{[1
]}

Yang, JY ^{[1
]}

Guo, M ^{[1
]}

Wu, CF ^{[1
]}

Wu, MF ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

来源：

BRAIN RESEARCH | 2005年 / 1040卷 / 1-2期

关键词：

morphine glutamate; anterior cingulate cortex; microdialysis;

D O I：

10.1016/j.brainres.2005.01.072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, we investigated the effect of morphine on the extracellular levels of glutamate in the anterior cingulate cortex (ACC) in freely moving rats using in vivo microdialysis coupled to high performance liquid chromatography and electrochemical detection. The results showed that either acute or chronic morphine treatment decreased the extracellular levels of glutamate in the ACC. Naloxone could reverse the decrease induced by chronic morphine treatment. The present study provided the first neurochemical evidence that morphine decreased extracellular levels of glutamate in the ACC, suggesting that glutamate in ACC is involved in the central actions of morphine. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：191 / 196

页数：6

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