Genetic liability to ADHD and substance use disorders in individuals with ADHD

被引：44

作者：

Wimberley, Theresa ^{[1
,2
,3
]}

Agerbo, Esben ^{[1
,2
,3
,4
]}

Horsdal, Henriette Thisted ^{[1
,2
,3
]}

Ottosen, Caecilie ^{[1
,2
,3
]}

Brikell, Isabell ^{[1
,2
,3
]}

Als, Thomas Damm ^{[1
,2
,5
,6
,7
,8
]}

Demontis, Ditte ^{[1
,2
,5
,6
,7
,8
]}

Borglum, Anders D. ^{[1
,2
,5
,6
,7
,8
]}

Nordentoft, Merete ^{[1
,2
,9
]}

Mors, Ole ^{[1
,2
,10
]}

Werge, Thomas ^{[1
,2
,11
,12
]}

Hougaard, David ^{[1
,2
,13
]}

Bybjerg-Grauholm, Jonas ^{[1
,2
,13
]}

Hansen, Marie Baekvad ^{[1
,2
,13
]}

Mortensen, Preben Bo ^{[1
,2
,3
,4
]}

Thapar, Anita ^{[14
]}

Riglin, Lucy ^{[14
]}

Langley, Kate ^{[14
,15
]}

Dalsgaard, Soren ^{[1
,2
,3
,4
]}

机构：

[1] IPSYCH Lundbeck Fdn Initiat Integrat Psychiat Res, Copenhagen, Denmark

[2] IPSYCH Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark

[3] Aarhus Univ, NCRR Natl Ctr Register Based Res, Dept Econ & Business Econ, Aarhus, Denmark

[4] Aarhus Univ, CIRRAU Ctr Integrated Registerbased Res, Aarhus, Denmark

[5] Aarhus Univ, ISEQ, Dept Biomed, Aarhus, Denmark

[6] Aarhus Univ, ISEQ, Ctr Integrat Sequencing, Aarhus, Denmark

[7] Ctr Genom & Personalized Med, Cent Reg Denmark, Aarhus, Denmark

[8] Aarhus Univ, Aarhus, Denmark

[9] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark

[10] Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark

[11] MHC Sct Hans, Mental Hlth Serv Copenhagen, Inst Biol Psychiat, Roskilde, Denmark

[12] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[13] Statens Serum Inst, Danish Ctr Neonatal Screening, Dept Congenital Disorders, Copenhagen, Denmark

[14] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Div Psychol Med & Clin Neurosci, Cardiff, S Glam, Wales

[15] Cardiff Univ, Sch Psychol, Cardiff, S Glam, Wales

来源：

ADDICTION | 2020年 / 115卷 / 07期

基金：

美国国家卫生研究院; 英国医学研究理事会; 英国惠康基金;

关键词：

Addiction; alcohol; attention-deficit; hyperactivity disorder; cannabis; conduct disorder; family history; polygenic risk; predictors; sex; substance use disorder; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; POLYGENIC RISK SCORES; CHILDREN; CHILDHOOD; ALCOHOL; ASSOCIATION; COEFFICIENT; HISTORY; COHORT;

D O I：

10.1111/add.14910

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Aims 1) To investigate whether genetic liability to attention-deficit/hyperactivity disorder (ADHD), indexed by polygenic risk scores for ADHD (PRS-ADHD), is associated with substance use disorders (SUD) in individuals with ADHD. 2) To investigate whether other individual- or family-related risk factors for SUD could mediate or confound this association. Design Population-based cohort study Setting and participants ADHD cases in the iPSYCH sample (a Danish case-cohort sample of genotyped cases with specific mental disorders), born in Denmark between 1981 and 2003 (N = 13 116). Register-based information on hospital diagnoses of SUD was available until December 31, 2016. Measurements We estimated odds ratios (ORs) with 95% confidence intervals (CIs) for any SUD as well as for different SUD types (alcohol, cannabis, and other illicit drugs) and severities (use, abuse, and addiction), with effect sizes corresponding to a comparison of the highest PRS-ADHD decile to the lowest. Findings PRS-ADHD were associated with any SUD (OR = 1.30, 95% CI: 1.11-1.51). Estimates were similar across different types and severity levels of SUD. Other risk factors for SUD (male sex, age at ADHD diagnosis, comorbid conduct problems, and parental factors including SUD, mental disorders, and socio-economic status) were independently associated with increased risk of SUD. PRS-ADHD explained a minor proportion of the variance in SUD (0.2% on the liability scale) compared to the other risk factors. The association between PRS-ADHD and any SUD was slightly attenuated (OR = 1.21, 95% CI: 1.03-1.41) after adjusting for the other risk factors for SUD. Furthermore, associations were nominally higher in females than in males (ORfemales = 1.59, 95% CI: 1.19-2.12, ORmales = 1.18, 95% CI: 0.98-1.42). Conclusions A higher genetic liability to attention-deficit/hyperactivity disorder appears to be associated with higher risks of substance use disorders in individuals with attention-deficit/hyperactivity disorder.

引用

页码：1368 / 1377

页数：10

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