Synthesis and biological activity of certain 1-substituted-4-benzylidene-2-phenyl-5-imidazolones

被引：0

作者：

Arief, MMH ^{[1
]}

机构：

[1] Benha Univ, Fac Sci, Dept Chem, Benha, Egypt

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1998年 / 37卷 / 06期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Substituted-4-benzylidene-2-phenyl-5-imidazolone derivatives 4-7, 9-15 have been synthesised for their potential biological activity. The synthesis involves the base and acid catalyzed reactions of azide 3 and/or acid chloride 2. Compounds 5c and 5d are easily cyclized to give 1,3,4-oxadiazole derivatives 6a and 6b. Representative examples of internal Friedel-Craft and [4+2]cycloaddition have also been investigated.

引用

页码：558 / 563

页数：6

共 12 条

[1] Synthesis of some saccharin derivatives of expected biological activity based on N-(saccharinyl)-acetic acid azide [J].

Arief, MMH .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1996, 114 (1-4) :129-134

[2]

ARYA K, 1991, CHEM REV, V91, P18

[3] 2,3-BENZOXAZIN-1-ONES .1. REACTIONS OF ALUMINUM-CHLORIDE, SULFURIC-ACID, AND HYDRAZINE HYDRATE WITH 4-ARYL-2,3-BENZOXAZIN-1-ONES [J].

BADDAR, FG ;

FAHMY, AFM ;

ALY, NF .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (21) :2448-2450

[4] ANTIBIOTIC SUBSTANCES SEPARATED FROM SUMAC [J].

CARLSON, HJ ;

DOUGLAS, HG ;

BISSELL, HD .

JOURNAL OF BACTERIOLOGY, 1948, 55 (05) :607-614

[5]

FAHMY AFM, 1986, INDIAN J CHEM B, V25, P308

[6]

Niedbalia V, 1981, CHEM ABSTR, V94, P15732

[7]

PANDE K, 1987, PHARMAZIE, V42, P269

[8]

STEIMECKE G, 1988, Patent No. 261782

[9]

Vincent JG, 1944, P SOC EXP BIOL MED, V55, P162, DOI 10.3181/00379727-55-14502

[10]

VOGEL AI, 1978, TXB PRACTICAL ORGANI, P885

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