Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis

被引：15

作者：

Scagnolari, Carolina

Midulla, Fabio

Trombetti, Siniona

Pierangeli, Alessandra

Tromba, Valeria

Grossi, Rosanna

Di Marco, Paola

Dianzani, Caterina

Girardi, Enrico

Antonelli, Guido

机构：

[1] Univ Roma La Sapienza, Dept Expt Med, Virol Sect, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Pediat, I-00185 Rome, Italy

[3] Univ Campus Bio Medico, I-00155 Rome, Italy

[4] Natl Inst Infect Dis, I-00149 Rome, Italy

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 232卷 / 10期

关键词：

bronchiolitis; interferon; RSV; rhinovirus; PKR; 2-5; OAS; P56;

D O I：

10.3181/0705-BC-124

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To determine whether there is an airway IFN response in infants with acute bronchiolitis and to establish whether the rate of such a response is related to the severity of illness, the expression of some IFN-induced genes was measured in nasopharyngeal washes from 39 infants with acute bronchiolitis. The results indicate that in infants with a virus-associated acute bronchiolitis there is a strong activation of IFN system and that the severity of illness is inversely related to the level of expression of IFN-induced genes. This suggests that the IFN response plays an important role in determining virus-associated respiratory disease in early life.

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收藏

页码：1355 / 1359

页数：5

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